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Multi Organ Synthesis > Vasculitis > Flashcards

Vasculitis Flashcards

1
Q

what are the constitutional symptoms of vasculitis?

A

weight loss and fever

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2
Q

what is sign of small vessel inflamm in kidneys?

A

active urinary sediment

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3
Q

what is sign of small vessel inflamm in lungs?

A

hemoptysis

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4
Q

what is sign of small vessel inflamm in skin?

A

petichiae purpura and hemorrhage

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5
Q

what are the three ANCA vasculitis?

A

GPA
eosinophilic granulomatosis with polyangitis
Micrscopic polyangitis

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6
Q

what systemic disease has vasculitis associated with it?

A

RA and SLE

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7
Q

what are the two non ANCA small vessel vasculitis?

A

IgA and ryoglobulinemic vasculitis

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8
Q

what is the medium vessel vasculitis?

A

polyarteritis nodosa

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9
Q

what are the two large vessel vasculitis

A

giant cell and takayasy

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10
Q

what are CNS signs of vasculitis?

A

stroke, wrist/foot drop

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11
Q

what is the target of c ANCA?

A

PR3

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12
Q

what vasculitis is c ANCA positive?

A

granulomatosis with polyangitis

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13
Q

what is pANCA target?

A

MPO

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14
Q

what vasculitis are associates with p ANCA?

A

microscopic polyangitis

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15
Q

what is another name for GPA?

A

wegeners

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16
Q

what is another name for eosinophilic granulomatosis with polyangitis?

A

churgg strauss

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17
Q

what does GPA effect?

A

upper and lower respiratory tract and kidneys

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18
Q

what is patho finding of GPA?

A

graulomatous inflammation of small vessels with extravascular granulomatous inflamaation and necrosis

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19
Q

what is GPA associated with?

A

cANCA

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20
Q

what is kidney finding in GPA?

A

pauci immune glomerulonephritis

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21
Q

what occurs in prodromal phase of EGPA?

A

rhinitis asthma and polyposis

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22
Q

what occurs in the secondary phase of EGPA?

A

eosinophilia develops

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23
Q

what can the eosinophilia cause in EGPA?

A

pulmonary pneumonia and gastroenteritis and myocarditis

24
Q

what is the hallmark of EGPA?

A

asthma

25
Q

does EGPA affect the kidneys?

A

nah not really

26
Q

what is seen on histo in EGPA?

A

eosinophilic necrotizing granuloma

27
Q

what ANCA is associated with EGPA?

A

p ANCA

28
Q

is MPA granulomatous?

A

NO

29
Q

what is most common vasculitis that causes a pulmonary renal syndrome?

A

MPA

30
Q

what is MPA positive for?

A

pANCA

31
Q

what two things does GPA have that MPA does not?

A

upper airway lesions and granulomas

32
Q

what is rx of ANCA vasculitis?

A

high dose steroids

33
Q

what is most common vasculitis in kids?

A

IgA vasculitis

34
Q

what precedes IgA vasculitis?

A

usually URI

35
Q

what are the three main signs of IgA vasculitis?

A

purpura
arthralgia
kidney disease

36
Q

what is pathologic finding on histo for IgA vasculitis?

A

leukocytoclastic vasculitis with deposition of IgA in walls of blood vessels

37
Q

type 1 cryoglobulin is what?

A

single monoclonal immunoglobulin

38
Q

what is Ig type in type cryoglobulin?

A

usually IgM

39
Q

type 2 cryoglobulin is what?

A

monoclonal Ig that acts against polyclonal Ig

40
Q

type 3 cryoglobulin is what?

A

polyclonal Ig that acta against polyclonal Ig

41
Q

what are cryoglobulinemic vasculitis often positive for?

A

rheumatoid factor

42
Q

C4 is low in what vasculitis?

A

cryoglobulin

43
Q

what is most common cause of cyroglobulinemic vasculitis?

A

hep C

44
Q

what does cryoglobulinemic vasculitis always involve?

A

SKIN

45
Q

what is mainstay of rx for cryoglobulinemic vascultiis?

A

steroid high dose

46
Q

what do you do if organ threatening situation with cryoglobulinemic vasculitis?

A

plasma exchange

47
Q

what is onset of polyarteritis nodosa?

A

insidious with onset of fever malaise weight loss

48
Q

what is common early finding of polyarteritis nodosa that tips you of?

A

arthralgia and myalgia

49
Q

what is PAN associated with in GI

A

mesenteric ischemia

50
Q

does PAN affect the lung?

A

NO

51
Q

what infection is PAN associated with sometimes?

A

HEp b

52
Q

where does fibromyalgia rheumatica affect

A

hips and shoulders

53
Q

what predates giant cell arteritis?

A

fibromyalgia rheumatica

54
Q

what does takayasu arteritis affect?

A

aorta and its branches

55
Q

what is rx for takayasu and giant cell arteritis?

A

high dose steroids

56
Q

name the four drugs that are common causes of ANCA vasculitis

A

cocaine
minocycline
propythiouracil
hydralazine

57
Q

what infection can lead to cryoglobulinemic vasculitis?

A

Hep C

Multi Organ Synthesis (9 decks)

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