Dermatomyositis Flashcards
polymyositis affects what muscles?
proximal muscle weakness
is polymyositis associated with a rash?
NO
how does inclusion body myositis onset?
over a number of years…slow
inclusion body myositis affects what muscles?
distal weakness more common
what is most common myopathy after 50 years old?
inclusion body myositis
what two things are involved in dermatomyositis?
muscles and skin
what muscles are affected in dermatomyositis?
proximal muscles
what is dermatomyositis often associated with?
malignancy
what three locations are often weak indermatomyositis?
hip and shoulder and neck flexors
what are three rashes commonly seen in dermatomyositis
helitrope rash
shawl sign
gottrons papules/sign
what is the shawl sign rash? what is it associated with?
looks like a cape on back sort of…asoc with dermatomyositis
what do juvenile cases of dermatomyositis often get on skin?
calcinosis
what is anti synthetase syndrome?
inflammtory myopathy (dermatomyositis) with raynauds, ILD and mechanics hand
what is mechanics hand associated with?
anti synthetase diseas
what is mechanics hand?
hand is worn out with lots of white scarrring
what ab is most associated with anti-synthetase syndrome?
anti-Jo-1
anti-jo-1 is against what?
anti histidyl tRNA synthetase
what two labs are elevated in dermatomyositis?
CK and aldolase
would an ESR and CRP be up or down in dermatomyositis?
UP for both
what antibody is often up in dermatomyositis?
ANA
what is a major comorbbidity in dermatomyositis?
ILD
what can be initial presentation of dermatomyositis?
ILD
what is amyopathic dermatomyositis?
when there are no muscle findings but there are skin manifestations
what is amyopathic dermatomyositis highly associated with?
ILD
what is antibody found in amyopathic dermatomyositis
anti MDA-5
what is prominent skin finding in amyopathic dermatomyositis?
skin ulcerations
dermatomyositis affects what part of muscles?
perivascular and perimysium
polymyositis affects what part of muscles?
endomysium
what immune cells mediate dermatomyositis?
CD4, macros, B cells
what immune cells mediate polymyositis that arent associated with dermatomyositis?
CD8 cells
name three abs found in dermatomyositis
anti-Mi2
anti TIF1y
Anti MDA5
what is anti Mi2 associated with in dermatomyositis?
worse weakness but less cancer risk
what is anti TIF1y associated with in dermatomyositis?
high cancer risk, but better muscle weakness
what is anti MAD5 associated with in dermatomyositis?
high association with ILD
what are common cancers in women with dermatomyositis?
breast and ovarian
what are common cancers in men with dermatomyositis?
prostate and lung
what is first line rx for dermatomyositis?
corticosteroids
name three second line options in dermatomyositis rx?
methotrexate, azathioprine and mycophenolate
