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Multi Organ Synthesis > Drugs > Flashcards

Drugs Flashcards

1
Q

what do steroids suppress the action of?

A

B and T cells by decreasing transcription of cytokines

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2
Q

what cells do steroids make apoptose?

A

T cells

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3
Q

what three endocrine issues can steroids cause?

A

cushing syndrome
osteoporosis
hyperglycemia
diabetes adrenocortical atrophy

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4
Q

what female repro issue can steroids cause?

A

amenorrhea for female

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5
Q

what can happen in GI with steroids?

A

peptic ulcers

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6
Q

what can happen to bone with steroids?

A

avascular necrosis and osteoporosis

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7
Q

what can happen with eyes in steroid use?

A

cataracts

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8
Q

what is the anti malarial used in SLE?

A

hydroxychloroquine

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9
Q

what is a secondary effect that HCQ has that helps with antiphospholipid syndrome?

A

slightly anti coagulant

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10
Q

what two situations mean you should not give HCQ?

A

retinopathy and G6PD deficiency

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11
Q

what should patients on HCQ have yearly?

A

eye exam for retinopathy

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12
Q

what are the two main side effects of hCQ?

A

rash and N/V

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13
Q

what is MoA of methotrexate

A

dihydrofolate reductase inhibitor…so decrease DNA synthesis

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14
Q

what four inflammatory conditions is methotrexate used in?

A

RA, IBD, psoriasis, vasculitis

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15
Q

what are the three main side effects of methotrexate?

A

nausea
fatigue
mucosal ulceration

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16
Q

what is biggest toxicity associated with methotrexate use?

A

hepatotoxicity

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17
Q

what pregnancy class is methotrextae?

A

class X

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18
Q

what is MoA of leflunomide?

A

enzyme inhibitor of dihydroorate dehydrogenase…leads to low levels of pyrimidine synthesis

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19
Q

what cell does leflunomide really inhibit production of?

A

T cells

20
Q

what is leflunomide often used for?

A

SLE RA and psoriatic arthritis

21
Q

what pregnancy category is leflunomide?

A

category X

22
Q

what is the MoA of azathioprine?

A

purine analog that inhibits the purine synthesis

23
Q

what molecule activated azathioprine?

A

HGPRT..turns it into 6-mercaptopurine

24
Q

what inflammatory disorders is azathioprine used for?

A

SLE, systemic vasculitis and myopathies

25
Q

what vasculitidies is azathioprine the maintenance therapy for?

A

ANCAs

26
Q

what are the main SEs of azathioprine?

A

GI, liver tox, myelosuppression!!!

27
Q

what three drugs can azathioprine interact with?

A

allopurinal, trimehtoprim, ACE inhibitors

28
Q

what pregnancy class is azathioprine?

A

not teratogenic

29
Q

what is MoA of mycophenolate mofetil?

A

reversibly inhibits IMP dehydrogenase to slow purine synthesis in B and T cells

30
Q

what is number one indication for mycophenolate mofetil?

A

lupus nephritis

31
Q

what are some indications for mycophenolate mofetil other than lupus nephritis?

A

SLE, scleroderma lung disease, vasculitis

32
Q

what is most common SE of mycophenolate mofetil?

A

dyspepsia…GI upset

33
Q

what can happen to bone marrow on mycophenolate mofetil?

A

myelosuppression

34
Q

what is the MoA of cyclophosphamide?

A

alkylates DNA…crosslinks at the guanine residues

35
Q

what is indication for cyclophosphamide in auto immine disorders?

A

SLE, vasculitis, systemic sclerosis

36
Q

name the three main SEs of cyclophosphamide

A

nausea
alopecia
myelosuppression

37
Q

what is risk with cyclophosphamide in GU?

A

hemorrhagic cystitis and bladder cancer

38
Q

how can you prevent bladder cancer and hemorrhagic cystitis when taking cyclophosphamide?

A

give MESNA

39
Q

what can happen to repro tract on cyclophosphamide?

A

infertility

40
Q

name the three most used TNF-a inhibitors

A

atanercept
infliximab
adalimumab

41
Q

what is big black box warning with TNF-a inhibitors?

A

TB re activation and Hpe B reactivation

42
Q

what is the MoA of rituximab?

A

MAB at CD20

43
Q

when is rituximab used

A

RA, ANCA vasculitis,

44
Q

name three adverse effects of rituximab

A

arthralgias
serum sickness
infections

45
Q

what is a major infection concern with rituximab?

A

reactivation of Hep B and PML

46
Q

what autoimmune conditions are indications for IVIG?

A

kawasakis
immune thrombocytopenia
SLE
inflammatory myopathy

Multi Organ Synthesis (9 decks)

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