Juvenile Arthritis Flashcards
what are a few non specific lab findings for juvenile arthritis?
elevated WBC
mild normocytic anemia
elevated ESR
elevated CRP
what does joint fluid analysis often show in juvenile arthritis?
inflammatory…so some WBCs but not too many
what three abs are found in juvenile arthritis?
anticyclic citrullinated peptide
RF
anitnuclear antibody
what is oligo juvenile arthritis?
when only less than 4 joints are involved
when does oligo juvenile arthritis onset?
ages 1-2
where does oligo juvenile arthritis usually affect?
lower extermities
what may co occur with oligo juvenile arthritis?
uveitis
what is Rf negative poly juvenile arthritis?
more than 5 joints affected and no Rheumatoid factor
when does RF negative juvenile polyarthritis onset?
1-3 yrs
what is positive in RF positive juvenile polyarthritis?
RF and anti CCP
when does RF positive juvenile polyarthritis onset?
9-11 yrs
where do rheumatoid factor abs bind?
the Fc portion of the IgG antibodies
what is enthesitis related arthritis?
arthritis accompanied by inflammation of tendon insertion sites
what is a common finding in enthesitis related arthritis?
SI joint tenderness and anterior uveitis
what is positive in enesthetis related arthritis?
HLA B27
who gets more juvenile arthritis?
females
who gets more enthesitis related arthritis?
boys
when is onset of enthesitis related arthritis?
late childhood/adolescence
what is finding of juvenile psoriatic arthritis?
arthritis, psoriasis, dactylitis, nail pitting, psoriasis in first degree relative
what are the two findings you have to have in systemic juvenile arthritis?
fever longer than two weeks and arthritis for 6 weeks
what are the four secondary findings in systemic juvenile arthritis?
evanescent rash, lymphadenopathy, enlargement of liver/spleen, serositis
what are symptoms of systemic juvenile arthritis?
fatigue, malaise, weight loss, myalgias, myositis
name the fever type associated with systemic juvenile arthritis
quotidian fever
what is a quotidian fever?
high fever1/2 times a day and return to baseline
what is the evanescent rash?
discrete small salmon pink macular lesions in systemic juvenile arthritis
where does the evanescent rash appear in systemic juvenile arthritis?
trunk and proximal extremities
what is a blood related issue that can occur in systemic juvenile arthritis?
macrophage activation syndrome
name the two IL-1 inhibitors used in systemic juvenile arthritis?
anakinra and canakinumab
what is the IL-6 inhibitor used in systemic juvenile arthritis?
tocilizumab
