Juvenile Arthritis

Question 1

what are a few non specific lab findings for juvenile arthritis?

Answer 1

elevated WBC
mild normocytic anemia
elevated ESR
elevated CRP

Question 2

what does joint fluid analysis often show in juvenile arthritis?

Answer 2

inflammatory…so some WBCs but not too many

Question 3

what three abs are found in juvenile arthritis?

Answer 3

anticyclic citrullinated peptide
RF
anitnuclear antibody

Question 4

what is oligo juvenile arthritis?

Answer 4

when only less than 4 joints are involved

Question 5

when does oligo juvenile arthritis onset?

Answer 5

ages 1-2

Question 6

where does oligo juvenile arthritis usually affect?

Answer 6

lower extermities

Question 7

what may co occur with oligo juvenile arthritis?

Answer 7

uveitis

Question 8

what is Rf negative poly juvenile arthritis?

Answer 8

more than 5 joints affected and no Rheumatoid factor

Question 9

when does RF negative juvenile polyarthritis onset?

Answer 9

1-3 yrs

Question 10

what is positive in RF positive juvenile polyarthritis?

Answer 10

RF and anti CCP

Question 11

when does RF positive juvenile polyarthritis onset?

Answer 11

9-11 yrs

Question 12

where do rheumatoid factor abs bind?

Answer 12

the Fc portion of the IgG antibodies

Question 13

what is enthesitis related arthritis?

Answer 13

arthritis accompanied by inflammation of tendon insertion sites

Question 14

what is a common finding in enthesitis related arthritis?

Answer 14

SI joint tenderness and anterior uveitis

Question 15

what is positive in enesthetis related arthritis?

Answer 15

HLA B27

Question 16

who gets more juvenile arthritis?

Answer 16

females

Question 17

who gets more enthesitis related arthritis?

Answer 17

boys

Question 18

when is onset of enthesitis related arthritis?

Answer 18

late childhood/adolescence

Question 19

what is finding of juvenile psoriatic arthritis?

Answer 19

arthritis, psoriasis, dactylitis, nail pitting, psoriasis in first degree relative

Question 20

what are the two findings you have to have in systemic juvenile arthritis?

Answer 20

fever longer than two weeks and arthritis for 6 weeks

Question 21

what are the four secondary findings in systemic juvenile arthritis?

Answer 21

evanescent rash, lymphadenopathy, enlargement of liver/spleen, serositis

Question 22

what are symptoms of systemic juvenile arthritis?

Answer 22

fatigue, malaise, weight loss, myalgias, myositis

Question 23

name the fever type associated with systemic juvenile arthritis

Answer 23

quotidian fever

Question 24

what is a quotidian fever?

Answer 24

high fever1/2 times a day and return to baseline

Question 25

what is the evanescent rash?

Answer 25

discrete small salmon pink macular lesions in systemic juvenile arthritis

Question 26

where does the evanescent rash appear in systemic juvenile arthritis?

Answer 26

trunk and proximal extremities

Question 27

what is a blood related issue that can occur in systemic juvenile arthritis?

Answer 27

macrophage activation syndrome

Question 28

name the two IL-1 inhibitors used in systemic juvenile arthritis?

Answer 28

anakinra and canakinumab

Question 29

what is the IL-6 inhibitor used in systemic juvenile arthritis?

Answer 29

tocilizumab