SLE Flashcards
do M or F get more SLE?
F
what are the two HLA genes that contribute to lupus?
prob HLA DR2 and 3
what t cells increase in SLE?
T2 and T17
what happens to B cells in SLE?
defective signaling and autoantibody production
what are C3/C4 levels in SLE?
commonly lower
what is the hallmark ab in SLE?
antinuclear antibodies
are anti nuclear abs sensitive or specific?
only sensitive
what is most reliable way to test for ANA?
IF
aside from ANA, what are other abs for SLE?
anti ds DNA and anti smith
what is test for finding anti ds DNA/
crithidia lucilae IF
when do autoantibodies show up in SLE?
often prior to onset
what are the three phases of SLE disease?
initiation
amplification and perpetuation
irreversible damage
what are signs of SLE flares? (4)
complement consumption
rising anti ds DNA titers
increased ESR
new lymphopenia
what are non specific symptoms of SLE?
fatigue, pain, memory, depression
what are consititutional symptoms of SLE?
malaise fatigue fever myalgia anorexia/weight loss
what can occur in oral area with SLE?
oral ulcers
what is skin sensitive to in SLE?
photosensitivity
what are two rashes of lupus?
malar rash…discoid lupus
what phenomenon can be found in SLE?
raynauds
what is most common msk finding in SLE?
arthralgia…symmetric inflammatory arthritis
what can happen to muscles in SLE?
inflammatory myopathy or fibromyalgia
what is elevates in inflammatory myopathy in SLE?
CPK/aldolase
what can happen to bone in SLE?
avascular necrosis
when is major risk of a CVA in SLE?
in first five years of disease
are CVA accidents in SLE ischemic or hemorrhagic?
usually ischemic
what is the leukopenia associated with SLE?
lymphopenia
what anemias can you have in SLE?
anemia of chronic disease
iron deficiency anemia
autoimune hemolytic anemia
what can happen to platelets in SLE?
thrombocytopenia
what is antiphospholipid syndrome?
autoantibodies to anionic phospholipids (cardiolipin) and their protein binding complexes
what is the main clinical manifestation of antiphospholipid syndrome?
thromboses
what type of thromboses occur in antiphospholipid syndrome?
arterial venous and pregnancy losses
what is the test for antiphospholipid syndrome?
russel viper venom time
what are the three abs in antiphospholipid syndrome?
anticardiolipin
anti B2 glycoprotein
lupus anticoagulant
what layer of heart can be affected in SLE?
any layer
what is most common layer of heart involved in SLE?
pericardium
what two malignancies are increased risk in SLE?
hodkins lymphoma and lung cancer
what are the three leading causes of mortality in SLE?
heart disease
malignancy
infection
what is the antimalarial most patients are on with SLE?
hydroxyshloroquine
what is the effect of hydroxychloroquine on SLE?
antgonist to TLR 3789 and decreases activation of innate immune system specifically plasmcytic dendritic cells
