Vasculitis

Question 1

P

Answer 1

Primary autoimmune
Secondary due to:
Infection
Connective tissue disease
drugs

Question 2

Polyarteritis nodosa

Answer 2

Necrotising arteritis
without glomerulonephritis
Aneurysm, thrombosis, infarction

GI - abdo pain
Heart - angina/MI
Kidney -HTN, renal failure
Mononeuritis multiplex

Question 3

Granulomatosis with polyangitis

Answer 3

Granulomatous inflamamtion of respiratory tract and glomerulonephritis
cANCA

Upper ariway obstruction
Espistaxis
Saddle nose deformity
Cavitary nodules 
Cough
Nephritic syndrome - haematuria, proteinuria, htn, uraemia

Question 4

Churg-strauss

Answer 4

Eosinophil rich granulomatous inflammation
Asthma
Eosinophilia
pANCA

Question 5

Anti-GBM disease

Answer 5

Glumerular capillaries, pulmonary capillaries
Deposition of anti-basement membrane autoantibodies

Goodpasture’s syndrome:
Anti-GBM antibodies
Glomerulonephritis
Pulmonary haemorrahge

Question 6

HSP

Answer 6

IgA dominant immune deposition
Children
Following URTI

Purpuric Rash on buttocks and legs
Arthritis
Abdominal pain

Question 7

Behcet’s syndrome

Answer 7

ORal ulceration
Genital ulceration
Ocular ant uveitis
Erythema nodosum
Arthiritis
GI
Neuro

Question 8

Mx:

Answer 8

Induce remission with high dose steroids
Taper steroid dose and use steroid sparing agent - methotrexate, azathioprine

NSAID analgesia