Polymyositis and Dermatomyositis

Question 1

P

Answer 1

PM is autoimmune connective tissue disease
Progressive symmetrical muscle weakness and myositis
May cause dysphagia, dysphonia, respiratory weakness

DM when there are skin pathology

Question 2

A

Answer 2

HLA B27
Bimodal age
Female
Black

Question 3

CF

Answer 3

Heliotrope rash on eyelids with oedema
Grotton’s papules - rough red papiles over knuckles
Macular rash
Nail fold erythema

Symmetrical proximal msucle weakness
Muscle pain
Aspiration pneumonia, dysphagia, dysphonia, resp failure

Question 4

Ix

Answer 4

Creatine kinase - 50x higher than normal
ESR/CRP raised

Anti-Jo
Anti-Mi-2
Positive ANA

Question 5

Mx

Answer 5

Prednisolone high dose
DMARDs
Steroid sparing agens
IVIg

Sun block
SALT
Monitor CK levels