SLE Flashcards
1
Q
P
A
Multisystem autoimmune disease
ANA antibodies
2
Q
A
A
Female
15-45
Afro-Caribbean, Asian
Drug-induced - isoniazid, phenytoin, sulfasalazine
3
Q
CF
A
Serositis - pleuritis, pericarditis Oral ulcers Arthritis Photosensitivity Blood disorders: - haemolysis - leucopenia - thrombocytopenia Renal disorder - proteinuria
ANA positive Anti-dsDNA Anti-Smith Antiphospholipid syndrome: Coagulation defect Livedo reticularis Obstetric - recurrent miscarriage Thrombocytopenia
Cutaneous lupus:
Malar rash - spares nasolabial folds
Discoid rash
4
Q
Ix:
A
ANA Anti-dsDNA Anti-Smith Anti-Ro/La Antiphospholipid antibodies Low Complement Positive direct Coomb's test
5
Q
Mx:
A
Sun protection
Smoking cessation
Pregnancy planned
NSAIDs for arthritis CVS risk reduction IA steroids Hydroxychloroquine High dose steroids and cyclophosphamide for severe
