Vancomycin

Question 1

Vancomycin
(Inhibit Cell Wall Synthesis - bactericidal)
(Narrow Spectrum)
(MRSA, Strept, Staph, Enterococci, C diff)

Answer 1

Prevents cross-linking of D-ala in the cell wall
Admin: Parenteral (Oral for C diff)
Penetrates all tissues (incl CSF and bone)
Renal excretion
Targets Gram + and anaerobes

Question 2

Resistance

Answer 2

Modification of terminal peptidoglycan motif (S aureus and enterococcus) preventing vanco from binding to D-ala

Question 3

Side Effects and Drug Interactions

Answer 3

SE: Childs, fever, skin rash, potential ototoxicity, flushing (red man syndrome) , renal toxicity
Requires Cp monitoring
DI: Increased risk of ototoxicity and nephrotoxicity with aminoglycodie use