Other Protein Synthesis Inhibitors

Question 1

Clindamycin
(Inhibits protein synthesis - bacteriostatic)
(Strept, Staph (MSSA, MRSA), C perfringens, B fragilis)

Answer 1

Binds to 50S subunit, inhibiting translocation of tRNA
Admin: Oral
High penetration, incl bone (exl CSF)
Hepatic Excretion
Works against Gram + and anaerobes

Question 2

Aminoglycosides
(Inhibits protein synthesis - bacteriostatic –> bacteriocidal)
(Pseudomonas, E coli, (Enterococci when in combo with Pen/Amp) )

Answer 2

Binds 30S subunit, inhibits initiation of translation, breakup of polysomes, and misreading the code
Admin: Parenteral (IV)
Concentrated in ECF, poor penetration in CNS/eye - accumulates in renal cortex and inner ear
Renal Excretion

Question 3

Resistance

Answer 3

AGs - anaerobes are resistant (as entry into bacteria is mediated by O2); Gram - plasmid uptake that mediates chemical modification of the drug/limit drug uptake

Question 4

Clindamycin:

Side Effects and Drug Interactions

Answer 4

SE: Cause of nocosomial (hospital-acquired) diarrhea (by C diff), pseudomembranous colitis, nausea, skin rash, (rarely impaired liver fxn and neutropenia)
DI: N/A

Question 5

Aminoglycosides:

Side Effects and Drug Interactions

Answer 5

SE: 8th nerve damage, renal toxicity, contact dermatitis, skin rashes, bone marrow depression, respiratory depression via neurotransmitter blockade
DI: Work synergistally with beta-lactams; inhibited by some penicillins