Cephalosporins

Question 1

Cefazolin (1st gen)
(Inhibit Cell Wall Synthesis - bactericidal)
(Strept, MSSA, E. coli)

Answer 1

Inhibit D-ala formation within cell wall
Admin: Parenteral
Penetrates most tissues except CNS
Renal Excretion
Targets Gram + and some Gram -

Question 2

Cephalexin (1st gen)
(Inhibit Cell Wall Synthesis - bactericidal)
(Strept, MSSA, E. coli)

Answer 2

Inhibit D-ala formation within cell wall
Admin: Oral
Penetrates most tissues except CNS
Renal Excretion
Targets Gram + and some Gram -

Question 3

Ceftriaxone (3rd gen)
(Inhibit Cell Wall Synthesis - bactericidal)
(N. Gonorrhoeae, Strept, MSSA, E. coli)

Answer 3

Inhibit D-ala formation within cell wall
Admin: Parenteral
Penetrates most tissues except CNS
Renal Excretion
Targets Gram - and some Gram +

Question 4

Resistance

Answer 4

MRSA 
Pseudomonas (only to Cephalexin)

Question 5

Side effects and Drug Interactions

Answer 5

SE: diarrhea, anaphylaxis, rash, convulsions, nausea, vomitting, nephritis, hemolytic anemia, thrombophlebitis, (superinfection with Ceftriaxone)
DI: may cross-react with penicilins