Vanco Carbapenems Monobactam

Question 1

What is aztreonam (Azactam)?

Answer 1

B-lactamase resistant monobactam

Question 2

MOA aztreonam?

Answer 2

Prevent peptidoglycan cross-linking by binding to PBP3

Question 3

Coverage of aztreonam?

Answer 3

G- rods ONLY

Question 4

What are the carbapenems?

Answer 4

Imipenem, meropenem (Merrem), ertapenem (Invanz), doripenem (Doribax)

Question 5

What must be admin with imipenem? Why?

Answer 5

Cilastatin, Decrease inactivation of drug in renal tubule

Question 6

Coverage of carbapenems?

Answer 6

G+ cocci, G- rods, anaerobes, WIDE SPECTRUM

Question 7

When is carbapenem use indicated?

Answer 7

After other drugs have been exhausted due to extensive side-effect profile

Question 8

MOA vancomycin?

Answer 8

Inhibiti cell wall peptidoglycan formation by binding D-ala-D-ala portion of cell wall precursors

Question 9

Vanco coverage?

Answer 9

G+ ONLY, serious infections (MRSA, Enterococci, C. diff)

Question 10

SEs of Vanco

Answer 10

Nephrotox, Ototox, Thrombophlebitis, Red Man Syndrome