Tuberculosis Tx Flashcards
1
Q
Tx for M. tuberculosis?
A
RIPE: Rifampin (Rifadin), Isoniazid, Pyrazinamide, Ethambutol (Myambutol)
2
Q
MOA INH?
A
Decrease synth of mycolic acid
3
Q
INH toxicity?
A
Neuro, hepato
4
Q
How to prevent INH neurotox?
A
Vit B6
5
Q
What are the Rifamycins?
A
Rifampin, rifabutin
6
Q
MOA Rifamycins?
A
Inhib DNA-dependent RNA polymerase
7
Q
SE of Rifamycins?
A
Orange body fluids, hepatotox, drug interaction (CP450 stimulation)
8
Q
What are the 4 Rs of Rifampin?
A
RNA pol inhib, Ramp up CP450 (rifAMPin only), Red/orange body fluids, Rapid resistance if monoTx
9
Q
SE of pyrazinamide?
A
Hyperuricemia, hepatotox
10
Q
Ethambutol MOA?
A
Decreased carb polymerizatin of mycobac cell wall by blocking arabinosyltransferase
11
Q
SE of Ethambutol?
A
Optic neuropathy (red-green color blindness)
