Penicillins

Question 1

What is the difference between Penicillin G and Penicillin V?

Answer 1

G is IV/IM and V is oral

Question 2

MOA for Penicillins?

Answer 2

Bind PBP and block crosslinking of peptidoglycans

Question 3

Bugs covered by Penicillin G/V?

Answer 3

Mostly G(+) (S. pneumo, S. pyogenes, Actinomyces), G(-) N. meningitidis and T. pallidum

Question 4

What bugs is Penicillin G/V bactericidal?

Answer 4

G(+) cocci (Staph, strep), G(+) rods (Clostridium, Bacillus, Mycobacterium), G(-) cocci (N. mening, gono?), spirochetes

Question 5

What are the aminopenicillins?

Answer 5

Ampicillin, amoxicillin

Question 6

To what are aminopenicillins susceptible to? Penicillin G/V?

Answer 6

Penicillinase

Question 7

What is the spectrum of aminopenicillins?

Answer 7

Mostly G(+) (S. pneumo, S. pyogenes, Actinomyces), G(-) N. meningitidis and T. pallidum + H. flu, E. coli, Listeria, Proteus mirabilis, Salmonella, Shigella, enterococci

Question 8

What is the mnemonic for aminopenicillins?

Answer 8

HELPSS kill enterococci

H. flu, E. coli, Listeria, Proteus mirabilis, Salmonella, Shigella, enterococci

Question 9

What are the penicillinase-resistant penicillins?

Answer 9

Oxacillin, nafcillin, dicloxacillin

Question 10

Coverage of PR-penicillins?

Answer 10

NARROW, S. aureus EXCEPT MRSA

Question 11

Mnemonic for PR-penicillins

Answer 11

“Use naf (nafcillin) for Staph”

Nafcillin, dicloxacillin, oxacillin

Question 12

What are the antipseudomonal drugs?

Answer 12

Ticarcillin, piperacillin

Question 13

What is the coverage for Ticarcillin and pipercillin?

Answer 13

Pseudomonas, G(-) rods

Question 14

What are the Beta-lactamase inhibitors?

Answer 14

Clavulanate, Sulbactam, Tazobactam