Valve Disorders Flashcards
Explain pathophysiology of mitral valve stenosis
Mitral valve stenosis = FIBROSIS + CALCIFIED – >
⬆️LA work in order to fill LV @ diastole –>
LA dilated + hypertrophied + stretched
= compress oesophagus = dysphagia –>
ConS Fib + Con Rahim
Pulmonary CCCONgestion = oedema + haemorrhage
–> Crackle hemoptysis Dyspnoea
Blood which should have passively emptied into LV gushes due to stenosis + ⬆️ contraction –>
Opening SSSSnap after S2
Atrial FIB –> stasis – > mural thrombosis
Pulmonary HTN - CONcentric RVH
Early mid diastolic rumble
What causes mitral valve stenosis
Chronic rheumatic fever
Women >man
Risk factors for mitral valve regurgitation
MRS IO SAMLIND
Mitral valve prolapse
Rupture posteromedial popular in muscle
Stretched mitral valve ring – functional regurg
Infective endocarditis
Other:
SLE, Acute RF, Myocarditis,
Libman sack, IHD, Nonbact thrombotic endocarditis, Dilated cardiomyopathy
What murmur you get in mitral valve regurg?
Radiate where?
What enhances the murmur?
Pansystolic regurgitant ‘blowing’ murmur
Radiate to axilla
Enhanced by manoeuvres that increase TPR eg squat/handgrip/expiration:
Because less blood will go through aorta and more through mitral valve
Expiration ⬆️blood entering LA –>
⬆️️BF out of aorta + ⬆️BF retrograde into LA
Explain pathphys of mitral regurgitation
MV regurg – >retrograde blood flow into LA – >
LA dilate = eccentric hypertrophy – >
More blood into LV = eccentric LVH
Not enough blood go forward due to regurg = LHF
What do you see clinically in mitral regurg
Dyspnoea, inspiratory crackles, hemoptysis
Risk factors for mitral valve prolapse
MR Chordae
- Marfans, Ehlors Danlos, Kleinfelter –>
myxoid degeneration =
Ground substance accumulation +
XS dermatan sulphate @ MV leaflet - Remitted fever
- Chordae rupture
Explain pathophysiology of mitral valve prolapse
@Systole –> chordae tenses = parachute open –>
Valve parachutes open =
REGURGITANT late systolic crescendo murmur
+
MID SYStolic CLICK
What is the effect of decreasing and increasing the preload?
⬇️preload –> ⬇systole LLLLLLENGTH –>
click + murmur move closer to S1
VICE VERSA FOR ⬆️preload
What factors decreased preload
What factors increased preload
Decrease preload:
- Standing – > ⬇️ VR –> ⬇️preload
- Anxiety – > ⬆️HR –> ⬇️filling time-> ⬇️️preload
- Valsalva manoeuvre (hold breath close epiglottis) -> ⬆️ Intrathoracic pressure –> ⬇️VR –> ⬇️preload
Increased preload:
- SSSupine/Recline – > ⬆️VR –>
- ⬆️️vol @ RH, lung, LH –> ⬆️preload
- SSSquat/handgrip–> ⬆️TPR –> ⬇️LV empty
What is the most common valve lesion in adults?
aortic stenosis < 1 cm^2
Normal = 4 cm^2
How does aortic stenosis occur?
If you have a bicuspid aortic valve what problem is there?
Increased trauma to aortic valve – >
⬆️Fibrosis + calcification –>
dystrophic calcification stenosis
2 Bicuspid valves = doing job of 3
What’s the difference between stenosis from
chronic rheumatic fever + stenosis from wear&tear
Chronic rheumatic fever
Always have
MITRAL stenosis +
AORTIC Stenosis with fusion of commissures
Stenosis from wearing tear only have aortic stenosis without fusion of the commissioners
Explain pathophysiology of aortic stenosis
Av sten ->
Cardiac compensation LV = push harder = concentric LVH ->
jet stream poststenotic dilation of aorta ->
Prolonged asymptomatic stage – maintenance and eventually blow open valve – >
Crescendo decrescendo Systolic ejection murmur = Blood rush through valve RADIATES to carotid
Explain the murmur you hear at aortic stenosis
Radiate where?
What is pulsus parvus et tardus
Splitting??
PanSystolic crescendo decrescendo ejection murmur
Radiate to carotid
Pulses = weak + delayed peak
Paradoxical splitting