Cardio Pharma Easy

Question 1

What do Na blockers do?

1a 1b 1c drugs?

Answer 1

Slow/block conduction ->
less steep phase 0 depol = slow it

1a quinidine procainimide disopyramide

1b lidocaine mexiletine

1c flecainide propafenone

Question 2

1a 1b 1c mechanisms

Answer 2

1a- ⬆️AP duration -> ⬆️effec refrac period

1b- ⬇️️AP duration

1c- prolong ERP @ AV node, NOT @ purk/ventricle

Question 3

1a 1b 1c uses

Answer 3

1a - atrial+vent arrhythmia

1b - ACUTE vent/DIGItalis induced arrhythmia

1c - SupraVent Tachycardia eg AFib

Question 4

Mechanism of class II

Use?

Answer 4

Beta blocker:

⬇️cAMP -> ⬇️Ca currents ->
⬇️phase 4 of pacemaker slope

For SVTs eg AFib/Flut, anxiety, MI, IHD

Beta blockers A-M = B1 selective

Question 5

Class III mechanism
Eg?
Use?

Answer 5

⬆️️AP duration -> ERP refractory
Basically when other antiarrythmics fail

Amiodarone!!!!! - check PFT’s TFT’s LFT’s

AFib/Flut + vent tachycardia

Question 6

Class IV mechanism?
Eg?

Thiazides mechanism

Answer 6

⬇️conduction velocity -> ⬆️ERP

_=PINES!!!! - @ SM
Vermapril - @ heart

Thiazides inhibit NaCl reabsorption

Question 7

Hydralazine + nitroglycerin mechanism.

HYPERtensive emergency?

Answer 7

Hydralazine -> ⬆️cGMP -> SM relax ->
art DILATE > veins -> ⬇️AFTERLOAD

Nitroglycerin -> ⬆️NO @ vasc SM -> ⬆️cGMP -> SM relax -> veins DILATE > art -> ⬇️Pre-LOAD

Nitroprusside - ⬇️afterload
Fenoldopam - ⬆️ natriuresis

Question 8

Antiarrhythmic classes

Answer 8

I - Na+
II - beta blocker
III - K+
IV - Ca2+