Vaccines - Robison

Question 1

List pros and cons of:

Live attenuated vaccines

Answer 1

Pros: do not need boosters, promotes both humoral and cell mediated immunity

Cons: may mutate back, usually has the most complications and side effects

Question 2

List pros and cons of:

Killed vaccines

Answer 2

Pros: more stable, no reversion, stores better

Cons: need boosters, humoral only, potentially dangerous if not killed allthe way

Question 3

List pros and cons of:

Subunit, purified macromolecules from pathogen

Answer 3

Same pros and cons as killed

Question 4

List pros and cons of:

Recombinant vector

Answer 4

Pros and cons the same as live attenuated

Question 5

List pros and cons of:

DNA plasmid carrying pathogen injected into the muscle

Answer 5

Pros: induces both cell mediated and humoral, very stable and customizable, prolong expression, enhanced memory

Question 6

What’s is an adjuvant?

Answer 6

Enhances immune response to antigens
Can be used in vaccines to boost the number of antibodies and lingering lasting protection

Examples: Alumn, MF59, Quil A

Question 7

What are the 4 types of acquired immunity and characteristics of each?

Answer 7

Natural Acquired Active Immunity
Getting immunity naturally from fighting infections

Natural Acquired Passive Immunity
Mother passing antibodies to fetus in utero

Artificial Acquired Active Immunity
Live attenuated vaccine

Artificial Acquired Passive Immunity
Receiving antibody serum