Antigen Presentation and MHC - Robison

Question 1

What is the difference between MHC class I and II?

Answer 1

Class I- interacts with CD8; endogenous

Class II- interacts with CD4; exdogenous

Question 2

How many different classes of MHC I are there in a human?

Answer 2

6

Question 3

How many different classes of MHC II are there in a human?

Answer 3

12

Question 4

Explain the difference between classical and non classical MHC

Answer 4

Classical- presents peptide antigens

Non-Classical - presents things other than peptide antigens

Question 5

Which MHCs site needs to have the peptides lay flat?

Answer 5

MHC II

Question 6

What does ubiquinone do?

Answer 6

It marks the proteins that need to be broken down by proteosomes

Question 7

What are TAP, calnexin, calreticulin, and tapasin?

Answer 7

Chaperone proteins for MHC I

Question 8

What does IFN-gamma do?

Answer 8

Activates macrophages as well as signals cells to upregulate chaperone proteins for MHC I

Question 9

Which enzyme degrades the invariant chain to allow MHC II to have antigens go on variant site?

Answer 9

CLIP

Question 10

Describe an immature dendritic cell

Answer 10

Good phagocytes
Do not have many MHCs on the cell surface
Express receptors that’s recognize inflammatory cytokines

Question 11

Describe a mature dendritic cell

Answer 11

Are not good phagocytes
Have many MHCs on the cell surface
Migrate toward the lymph nodes
Can activate an naive T cell

Question 12

How can a naive T cell tell if a dendritic cell is mature or spontaneously matured?

Answer 12

Mature dendritic cells have B7 on the cell surface from PAMPs
Spontaneously matured dendritic cells will not have this on the cell surface and will go through anergy