Transplantation- Mandal

Question 1

What are the testing methods to check donor and recipient compatibility?

Answer 1

ABO testing- blood test
Tissue typing- HLA testing
Tissue cross matching- making sure Ab will not react with donor WBCs

Question 2

Determine what kind of drug and cells the immunosuppressant effects:

Sandimmune, prograf

Answer 2

Calcineurin

T-cells

Question 3

Determine what cells the immunosuppressant effects:

Rapamune or rapamycin

Answer 3

mTOR

t-cells

Question 4

Determine what cells the immunosuppressant effects:

Atgam, OKT3

Answer 4

Anti-T antibodies but effects T,B, and platelets

Question 5

Determine what cells the immunosuppressant effects:

Zenapax, simulect

Answer 5

IL2 receptor antagonist

T-cells

Question 6

Determine what cells the immunosuppressant effects:

Imuran, cellcept

Answer 6

Anti metabolite

Decreases purine synthesis in B and T cells

Question 7

Determine what cells the immunosuppressant effects:

Orasone, deltasone, methylpred, solumedrol

Answer 7

Corticosteroid
Decreases the entire inflammatory response
Effects B and T cells

Question 8

What is GVHD?

Answer 8

Graft vs host disease
Donor lymphocytes attack the graft recipient
Sometimes causes oral mucosal erosions

Question 9

Who would need an organ transplant?

Answer 9

A person who has irreversible organ damage and alternative treatments are not working