Autoimmune Diseases - Mandal

Question 1

What is central tolerance?

Answer 1

For immature lymphocytes in the primary lymphoid organs

Kill self reactive cells
Change the BCR
Tregs regulate inflammatory action

Question 2

What’s is peripheral tolerance?

Answer 2

For mature lymphocytes in secondary lymphoid tissue

Anergy
Cell death
Suppression by Tregs by IL10 and TGF-beta

Question 3

Mucosal uses what kind of tolerance mechanisms?

Answer 3

Anergy
Deletion
Tregs

Question 4

What’s autoimmune diseases involve autoantibodies?

Answer 4

MS: Ab against myelin protein
RA: Ab against synovial fluid
SLE : Ab against nuclei can acids

Question 5

What are the autoimmune diseases involving cell receptors?

Answer 5

Graves’ disease: Ab stimulates the receptor with out ligand which results in overactive TSH
Myasthenia Gravis: Ab binds to Ach receptor which results in muscle weakness and paralysis

Question 6

What are tissue specific autoimmune diseases that T cells target?

Answer 6

IDDM: Tcells attack islet cells
Hashimotos: T cells attack thyroid gland, hyperthyroidism
Autoimmune hemolytic anemia: attack RBCs

Question 7

What is an autoimmune disease?

Answer 7

Failure of the immune system to recognize self cells