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Phar 210 > Vaccine and Immunotherapeutics > Flashcards

Vaccine and Immunotherapeutics Flashcards

1
Q

What are the drawbacks to an inactivated viral vaccine?

A
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2
Q

Do you need to refrigerate the inactivated viral vaccine?

A

No

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3
Q

What are the disadvantages of live attenuated vaccines?

A

The microbe has been weakened and people with weakened immune systems cannot be given live vaccines

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4
Q

Where do you store live vaccines?

A

Fridge

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5
Q

Is their a possibility that the live vaccine could revert to a virulent form?

A

Yes

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6
Q

What is a protein based vaccine

A

Subunit vaccine that uses a subunit (spike) to develop antigents

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7
Q

How many different antigents can a subunit vaccine contain?

A

1 to 20

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8
Q

What is a viral vector vaccine?

A

where the gene for a pathogen protein is inserted into a different virus without causing disease

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9
Q

What is a nucleic acid vaccine?

A

Nucleic acid coding for the antigen is injected

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10
Q

What are toxoid vaccines?

A

For bacteria that secrete toxins that are harmful chemicals, they serve to inactivate the toxins by treating with formalin

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11
Q

take some time to review the next slide

A
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12
Q

Example of Attenuated live virus

A

Measeles, yellow fever

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13
Q

Whole inactivated virus?

A

Rabies, hep aP

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14
Q

Protein subunit vaccine?

A

Influenza

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15
Q

Recombinant vaccine?

A

Hep B

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16
Q

Replicating or non-replicating viral vector?

A

Ebola

17
Q

Nucleic acid vaccine

A

Covid-19

18
Q

What is a good vaccine?

A
19
Q

What is self-amplifying mRNA?

A

mRNA that is engineered to make more copies of itself once delivered into cells

20
Q

What is the usage of micro-spheres of polymer?

A

Can relase the vaccine into the body at day one and day 21 (Delayed release and gives a boost!

21
Q

How many micrograms did the covid vaccines generally were?

A

30-100

22
Q

What is a conjugate vaccine?

A

Generally given in infants where the antigen is coated in polysaccharides so that the body does not recognize or respond to the coating.

23
Q

When making a conjugate vaccine scientists like?

A
24
Q

Polysaccharides are sugars that are very

A

Hydrophilic

25
Q

What is Bexerso?

A

Consists of 4 antigenic components chosen to achieve broad protetion from MenB

26
Q

What is Placizumab

A

Approved therapeutic AB treatment that targets RSV and does not allow it to enter cell

27
Q

What was the issue with the RSV early vaccine

A

Made disease worse because the Trimeric F protein of RSV undergoes major conformational changes hence the target changes

Therefore DS-CAV1 used which induced 10 times the level of neutralizing antidbodies as a vaccine with postfusion F did in a study

28
Q
A

Phar 210 (10 decks)

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