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Phar 210 > Nanotechnology > Flashcards

Nanotechnology Flashcards

1
Q

What is an advantage of a novel delivery system?

A

Target the drug to the diseased area, lower the side effects and enhance the efficacy

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2
Q

What cancer therapies have been succesfully formualted using nanomaterials/

A

Paclitaxel, Doxorubicin, 5-fluorouracil. dexamethasone

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3
Q

What are the common bases of nanotech?

A

PLGA and PLA

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4
Q

What is the difference between passive targeting and active targeting?

A

Passive: Tendency of unmodified delvier ysstem to gather in specific tissues

Active: utlilizes a ligand on the surface of the novel deliver system

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5
Q

What are the 6 drug delivery carriers?

A

Micelles, Vesicles, Multifunctional dendritic polymers, nanospheres, nanocapsules, liquid crystals

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6
Q

What is the approxiamte size of a liposome?

A

100nm

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6
Q

What are the classes of polymer therapeutics?

A
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7
Q

What are the classes of lipid based delivery systems/

A
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8
Q

What are the polymer drug/protein conjugates?

A
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9
Q

What are polyplexes?

A
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10
Q

What are dendrimers?

A

3 components which include initiator core
Interior layers composed of repeating units attached to interior core
Exterior attached to the outermost interior layers

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11
Q

What is a micelle?

A

Self assembly of amphiphilic polymers or surfactants

CMC*

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12
Q

What is the CMC point we attempt to reach?

A
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13
Q

What is a SLN?

A

Solid lipid nanoparticle
Size 50-1000nm
Matrix is solid lipids or mixtures of lipids

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14
Q

Review the next slide about the different types of SLN

A
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15
Q

What are nanoemulsion?

A

Lipid monolayer enclosing a liquid lipid core ***Liquid is key

16
Q

How do you form nanoemulsions or SLN?

A

High pressure homogenization

17
Q

What are liposomes?

A

These have 2 layers like a cell where the core ncloses water or aqueous soln

18
Q

What are nanocapsules?

A
19
Q

What are nanospheres?

A
20
Q

What are polymeric nanoparticles?

A

Solid, colloidal particles consisting of artificial or natural polymers where the drug is dissolved entrapped in a encapsulated polymer

21
Q

What is a key characteristic of a polymer?

A

Must be biocompatible and degredable and nontoxic

22
Q

What is PLGA?

A

Both biocompatible and biodegradable

23
Q

What is the global market of nanoparticles?

A

83.4 billion in 202 to 123.6 billion in 2025

24
Q
A

Phar 210 (10 decks)

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