Targeted therapies for breast cancer

Question 1

For treatment of stage 1 b-cancer what is the primary treatment?

Answer 1

Question 2

What is the stage II treatment

Answer 2

Question 3

What is the stage III treatment?

Answer 3

Question 4

What is the stage IV treatment of breast cancer?

Answer 4

Question 5

What is the worst kind of breast cancer?

Answer 5

Triple negative marker ER, PR, HER2

Question 6

What is Luminal A?

Answer 6

ER+ PR + HER2-

Question 7

What is luminal B

Answer 7

ER +, PR +, HER2+

Question 8

What are the antibodie treatments for Her2

Answer 8

Trastuzumab, pertuzumab, margetuximab

Question 9

What is the binding domain of trastuzumab?

Answer 9

Subdomain IV of Her2 protien

Question 10

What is the binding domain of Pertuzumab?

Answer 10

Subdomain II of her2 protein and blocks homodimerization of Her2

Question 11

What is the Binding target of margetuximab?

Answer 11

Chimeric IgG monoclonal antibody that binds to extracellular domain of HER2

Question 12

What is T-DM1

Answer 12

Emtansine (DM1), will be attached and is a potent cytotoxic agent

Question 13

What is Fam-trastuzumab deruxtecan?

Answer 13

Used for unresectable her2 positive breast cancer

Question 14

WHat are the TKIs?

Answer 14

Question 15

What is lapatinib?

Answer 15

Question 16

What is Neratinib?

Answer 16

Question 17

What is Tucatinib?

Answer 17

Question 18

What are the 3 cdk4/6 inhibitors/

Answer 18

Question 19

What is palbociclib?

Answer 19

Question 20

What is Ribociclib?

Answer 20

Question 21

What is Abemaciclibn?

Answer 21

Question 22

What is everolimus?

Answer 22

Question 23

What is Alpelisiob?

Answer 23

Question 24

What is Olaparib?

Answer 24

Question 25

What is Talazoparib?

Answer 25

Question 26

What is the purpose of PARP?

Answer 26

Question 27

What is Sacituzumab Govitecan?

Answer 27