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Phar 210 > All things before the final > Flashcards

All things before the final Flashcards

1
Q

What is the half-life of Taq?

A

30 minutes at 95

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2
Q

How long is a PCR cycle

A

1 minute

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3
Q

What is the usage of SYBR green or taqman?

A

Helps detect when annealing/extension is done

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4
Q

How do we introduce mutagenesis into PCR?

A

Taqman poor proofreading
Unequal amounts of nucleotides
Mn or Mg

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5
Q

What is the function of the primary metabolite?

A

Performs normal physiological functions such as cell growth

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6
Q

What is the intermediary metabolite?

A

Maintains homeostasis such as energy intermediates

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7
Q

What are the 4 areas of metabolomics?

A

Sugars
Lipids
Amino acids
Nucleotides

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8
Q

What are the three components important for LC?

A

Resolution
Column
Flow rate

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9
Q

Equation for calculation of RS?

A
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10
Q

Small particle size means

A

higher pressure and better resolution

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11
Q

Loss of resolution occurs at?

A

High flow rate

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12
Q

What is normal Phase HPLC?

A
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13
Q

What are non polar and polar stationary phases/

A
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14
Q

What is reverse phase HPLC?

A
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15
Q

What is the column pressure of UPLC?

A

1030 BAR

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16
Q

What is important to know about Gas chromatography?

A

Polar tube for Polar substance
Non-Polar tube for non-polar substance

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17
Q

What is the substance that makes up GC cap columns?

A
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18
Q

What are the carrier gasses for Gas chromatography?

A

Helium
Hydrogen
Nitrogen

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19
Q

How many drugable targets have been identified in the human genome?

A

3000+

20
Q

What is pharmacogenetics/

A
21
Q

What is pharmacogenomics?

A
22
Q

What metabolizes warfarin?

A

CYP2C9

23
Q

What does CYP4F2 do?

A

Reducing the amount of Vitamin K

24
Q

What does VKORC1 do?

A

Recycles vitamin K for usage

25
Q

Which class of CFTR leads to no activity?

A

Class III and Class VI

26
Q

What is ataluren?

A

Class I CFTR mutation fixer that has the power to overcome the effects of a non-sense mutation

27
Q

What does Kalydeco do?

A

Open CF patients channels

28
Q

What does trikafta do?

A

Bring the transporters to the surface

29
Q

What is Fomivirsen/’

A

Cytomegalovirus treatment

30
Q

What is Mipomersen?

A

Homozygous familial hypercholesterolemia

31
Q

What does Exondys 51 do?

A

Exon skipping

32
Q

What does Spinraza do/

A

It activates the SMN2 gene and allows for the increased production of SMN protein, leading to improved spinal muscular atrophy

33
Q

What is PROTACS?

A
34
Q

What is the mechanism of resistance for BCR-ABL dependent and independent

A

Essentially mutations to the BCR-ABLE gene

35
Q

How does Imatinib work?

A

Binds in the pocket of BCR-ABl to stop the binding of ATP

36
Q

What is the ending for tyrosine kinase inhibitors?

A

Tinib

37
Q

What does Entrectinib do?

A

Inhibitor of TRK, ALK and ROS1

38
Q

What does Larotrectinib do?

A

TRK inhibitor

39
Q

What does Trastuzumab do/

A

Bind to subdomain IV of HER2

40
Q

What does pertuzumab do?

A

Prevent dimerization

41
Q

What is Enhertu?

A

Trastuzumab and payload

42
Q

What is Cetuximab?

A

EGFR1 inhibitor

43
Q

What are bispecific antibdoeis?

A

Have the two ends where they can bridge t cells and target antigen

44
Q

What does heterogeneity mean?

A

Not all cells in the tumour are of one type and ehnce will not interact iwth one single targeted therapy

45
Q

What MHC class interactors with T helper cells?

A

Class I and Class II

46
Q

What MHC class interacts with CD8 T cells?

A

Class I

47
Q
A

Phar 210 (10 decks)

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