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Step 1 QBANK Qs > UWORLD NEURO/PSYCH PHARM > Flashcards

UWORLD NEURO/PSYCH PHARM Flashcards

1
Q

Pt with 6-12 Hz tremor of upper extremity over the last 10 years. Tx?

A

Essential Tremor. Beta Blocker

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2
Q

Migraine drug that can cause hypertensive crisis?

A

sumatriptan

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3
Q

Sumatriptan MoA

A

5HT1b/1d AGONIST

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4
Q

MoA MG drugs?

A

Pyridostigmine. Carbamylates AChE to inactivate it.

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5
Q

Drugs that phosphorylate AChE?

A

nerve gases. Sarin.

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6
Q

Depressants that can cause glaucoma?

A

TCAs - anticholinergic effects

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7
Q

Use and MoA of Cyclobenzaprine?

A

Muscle relaxant. blocks ACh.

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8
Q

AChE inhibitor OD. Tx?

A

parlidoxime. Reactivates AChE (decreases ACh)

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9
Q

OD on anticholinergic. TX?

A

physostigmine.

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10
Q

No wine/cheese with what drugs?

A

MAO-I

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11
Q

Antimuscarinic used in PD?

A

Benztropine, Trihexyphenidyl

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12
Q

Ocular pain with halos?

A

Glaucoma

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13
Q

2 distinct ways to Treat Parkinsons?

A

increase DA, decrease ACh

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14
Q

AMPH MoA?

A

reverses reuptake transporter

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15
Q

Don’t give these drugs to a bipolar patient in a mania phase

A

TCA

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16
Q 
Mood stablizing drugs: 
Principal agents (2)?
anti-seizure?
atypicals?
other class?
A

Li, valproate
Carbamazapam
Olanzapine, clozapine
Benzos

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17
Q

Pt with controlled MG, comes in with MG symptoms. Give edrophonium. If symptoms improve? If they don’t?

A

1) Give more drug

2) cholinergic crisis. Stop drugs

18
Q

Penicillans MoA?

A

bind to transpeptidases (PBPs) that crosslink cell wall. Do not bind to wall itself.

19
Q

Organophosphates/pesticides MoA?

A

irreversible inhibit AChE -> increases ACh

20
Q

Organophosphate poisoning. Problem with atropine? DoC?

A

Will only reverse effects at Muscarinc receptors (no effect on muscle). Pralidoxime is DoC - reactivates AChE.

21
Q

Advantages/Disadvatages of buspirone?

A

no hypnotic, sedative, or euphoric effects but takes 2 weeks to work

22
Q

GABA A vs B vs C? (location, type of channel)

A

Brain, ion channel
Brain G-protein
Retina, Ion channel

23
Q

Tx: Malignant Hypertension vs Neroleptic Malignant syndrome vs Serotonin Syndrome

A

Dantrolene vs Dantrolene/D2 ags vs Cyproheptadine (5HT2 antag)

24
Q

Dantrolene blocks what Receptor?

25
Q

All inhaled anesthetics have this undesirable effect?

A

increase blood flow to Brain increasing ICP

26
Q

Anti-depressant without any sexual side effects?

27
Q

Drugs that can result in serotonin syndrome:

Analgesic?

28
Q

How secondary MoA that causes antibiotic to cause serotonin syndrome?

A

Linezoid. Weak MAO-I activity

29
Q

Supplement that increases peripheral metabolism of L-dopa?

A

Multivitamin, specifically Vit B6

30
Q

Chemoprophylaxis for menigococcus?

31
Q

Entacopone and Tolcapone. MoA?

A

COMT inhibitors. Decrease peripheral degradation of L-Dopa.

32
Q

Opioids that are weak Mu-agonists (can trigger withdrawl in pts high on opioids).

A

butrorphanol, pentazocine

33
Q

Antiseizure drug that is metabolized to phenobarbitol?

34
Q

Psychosimulant drug for narcolepsy?

35
Q

Drugs that can result in serotonin syndrome:

Anti-emetic?

A

5HT3 receptor antagonist (ondansetron)

36
Q

Drugs that can result in serotonin syndrome:Antibiotic?

37
Q

Drugs that can result in serotonin syndrome: Neuropsychiatric?

38
Q

Benzos that will increase fall risk?

A

Long acting benzos:

Cblordiazepoxide, Clorazepate, Diazepam, flurazepam

39
Q

To treat TCA-related cardic problems?

40
Q

Effect of ACh on endothelial cells?

A

release of NO

41
Q

Li toxicity in increased what what type of drugs?

A

NSAIDs, Thiazides, ACE inhibitors

42
Q

MoA of TCA cardiotoxicity?

A

blocks cardiac Na channels

Step 1 QBANK Qs (20 decks)

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