Heme/Onc UWORLD

Question 1

Hemolytic anemia. Appearance of Iron in macrophages?

Answer 1

yellow brown pigment. Fe forms ferritin mycelles and form hemosiderin.

Question 2

Mongoloid facies?

Answer 2

Extra medullary Hematopoiesis. B-thalessemias

Question 3

carbon tetrachloride - effect on cells?

Answer 3

causes free radical injury. Forms H2O2.

Question 4

Coagulation disorder with decreased fibrinogen?

Answer 4

DIC

Question 5

Receptor that induces cytokine release?

Answer 5

TLR

Question 6

Rb active vs inactive form?

Answer 6

HYPOphosphorylated = active (no progression to s-phase)

hyperphosphorylated = inactive (progression to s-phase)

Question 7

Monoclonal Antibody to what?
Infliximab
Imantinib
Rituximab
Abciximab

Answer 7

TNF-a
BCR/ABL
CD20
GPIIb/IIIa

Question 8

Pt with presistent infection and hemorrhage - leukemia?

Answer 8

PML

Question 9

Receptors for Vit A derivatives - leukemia?

Answer 9

AML

Question 10

Integrins bind to?

Answer 10

Collagen, fibronectin, Laminin

Question 11

Function of:
Heparan sulfate
Hyalyronic acid
Keratan sulfate

Answer 11

contributes to vascular endothelial cell attachement
water retention in ECM
Maintains collagen I organization in cornea

Question 12

Firm brown spleen indicates?

Answer 12

vasulcar occlusion

Question 13

Facter V leiden - predisposes to thrombi where?

Answer 13

deep veins

Question 14

primary CNS lymphoma. Seen in?

Answer 14

AIDS pts

Question 15

These drive vasculogenesis in tumors?

Answer 15

VEGF - new capillaries

FGF - Endothelial proliferation, migration and differentiation

Question 16

Epidermal growth factor?

Answer 16

Mitogenic influence on epithelial cells, hepatocytes and fibroblasts

Question 17

Somatomedian C?

Answer 17

insulin-like growth factor

Question 18

Anabolic steroids - effect on Blood?

Answer 18

increases RBC production.

Question 19

Obstructive sleep apnea - blood changes?

Answer 19

hypoxia causes kidneys to release EPO.

Question 20

Cause of skin changes in breast cancer?

Answer 20

Obstruction of lymph drainage

Question 21

Pt with sickle cell. Prone to a type of nutritional deficiency that leads to?

Answer 21

Folate deficiency from high cell turnover. Megaloblastic anemia.

Question 22

Pt with lifelong hx of gingival bleeding and epistaxis?

Answer 22

vWF deficiency

Question 23

Systemic inflammatory response induced by?

Answer 23

IL-1, IL-6, TNF-a

Question 24

Bone marrow of pt shows absence of erythroud precursors but preserved myeloid and megakaryocytic elements. Possbile Causes?

Answer 24

Thymoma, lymphocytic leukemias, parvovirus

Question 25

EBV - cancers?

Answer 25

Burkitt lymphoma; nasopharyngeal CA

Question 26

Dysplasia?

Answer 26

Reversible change

Question 27

Pancytopenia in lupus. Cause?

Answer 27

Hemolysis of cells

Question 28

DDAVP used for tx of? (mech)

Answer 28

Hemophilia A and vW deficiency. Releases both from endothelial cells

Question 29

Pt with thromboses. PTT doesn’t increase after protein C is given.

Answer 29

Factor V leiden

Question 30

Peroxidase will stain for what cancerous cells?

Answer 30

AML - stain auer rods

Question 31

CD55 and CD59 deficiency? Mech?

Answer 31

paroxsymal nocturnal hb-uria. Complement over activation/

Question 32

ristocetin positive?

Answer 32

vWF deficiency

Question 33

Pt with cervical lymph node whose size flucctuates over time. Cancer?

Answer 33

follicular adenopathy