Uworld Endocrine Review Flashcards
all the shit you dont know.
65 m has dec apetite, nausea, abdominal bloating, and early satiety. Has longstadning type 2 DM, with retinopathy, takes insulin. What would be most helpful. (and what does he have)
Metoclopramide or erythromycin- he has gastropareisis. think like Diabetic neuropathy of the gut. Also do smaller meals with more fiber.
If a patient had predominantly emesis. What do you give.
Diphenhydramin, ondansetron
4 month old boy had a seizure. had 3 epidsode of URI and OM. hes ate the 5th percentile for weight, has round cheeks and a doll like face. Liver is palpable. Labs: hypoglycemic, and lactic acidosios, ketonuria, hypertriglyceridemia and uremia. What is the dx and cause?
Impaired glycogen to glucose conversion - they have Glucose-6-Phosphatase deficiency. aka von Gierke
Describe von gierke disease
cannot convert glycogen to glucose due to deficiency of Glucose 6 phosphatase deficiency. Glycogen accumulatation in liver. See hypoglycemia, lactic acidosis, hyperuricemia, hepatomegaly
Describe MCAD
inability to break fatty acid chains. hypoketotic hypoglycemic during fasting states.
Describe Gausher disease - what is deficient
Glucocerebrosidase ezyme deficiency - see accumulation in macro[hages i liver, spleen, and bone marrow causing bone pain and cytopenias.
26 female - routine visit 6 months after birth of kid. anxiety, fatigue, irritable, constipation, gained weight, hypertension, LExt. Edema, Hyponatremia, high cholesterol. What test do you do first?
Thryoid function studies - she has post partum thyroiditis.
What situation would you choose “Early morning cortisol?”
Adrenal Insufficiency - so low cortisol, hyponatremia, hyperkalemia, hypotension, hypoglycemia
malnourished homeless man has recurrent abdominal pain, muscle cramps, and periooral numbness. He is found to have Hypocalcemia, as well as low potassium, MCV 104, Mg 0.8, Phos 2.0, Albumin 3.4. What is the most probably cause of hypocalcemia here.
Hypomagnesemia and hypophosphatemia. Normal Mg is 1.5 - 2.0. Normal Phos is 3-4.5
What is the approach to assessing Hypocalcemia?
Repeat , correct with albumin, chek Mg/Drug/Transfusion, Then measure PTH.
When would you suspect calcium deposition as the cause of the hypocalcemia
when there hyperphosphatemia, osteopblastic metastasis, and acute pancreatitis.
In panhypopituitarism, what hormones is NOT affected?
Adrenal aldosterone - its affected by the RAAS.
Why does hyponatremia in HHNKS doesnt matter?
this is PSEUDOhyonatremia from the hyperglycemic state.
Why is HHNKS hyperosmolar and yet theres hyponatremia?
the high osmolarity is from the glucose.
When do you AVOID TCAs from neuropathic pain?
Anticholinergic effects in the elderly, >65
