Uworld 4 Flashcards
cromlyn MOA
inhibits mast cell degranulation
lots of candida means
likely HIV
goes with EBV and EBV lymphomas
metyropone
blocks cortisol synthesis
to test HPA axis
renal cell carcinoma goes with what genetic disease
VHL
chromosome 3p
autosomal dominant
homocysteinuria
looks like marfans
give pyridoxine (B6)
autosomal recessive
lack of cystathionine beta-synthase
ischemic stroke microscopic timeline
12-24 hrs “red neurons,” eosinophilic, loss of Nissl
24-72 hrs neutrophil infiltration
3-7 days macrophages
1-2 weeks reactive gliosis, vascular prolif
> 2 weeks glial scar
SVC syndrome vs brachiocephalic
SVC- both sides
brachiocephalic- one side
ang II does what
systemic vasocontriction
increased efferent arteriole constriction
enhanced aldosterone secrtion.
Inhibit it? –> decreased resistance (systemic and efferent) and decreased GFR
check phospholipids in preggo why?
surfactant
fidoxomicin
macrocytic abx
vs sigma of RNA polymerase
use for C. diff
CO–>
increased carboxyhemoglobin NOT methemoglobin (drugs, nitrites, enzyme defish)
genetic suceptibility to TB
IFN gamma deiciency
Severity: ODD, conduct disorder
ODD is not as bad
conduct disorder- violate the rights of others
ureters are anterior to
internal iliac artery
Rx ventricular arrhythmias
- amiodarone
2. lidocaine- preferentially binds rapidly depolarizing and ischemic ventricular fibers
mitochondrial myopathy
ragged red fibers
neuropathy, seizures
mitochondrial inheritance
niacin compensatory pathway uses what?
tryptophan
heart disease associatd pulmonatry HTN pathogenesis
pulmonary venous congestion
epilepsy med vs voltage gated Ca+ channels –>
affects fusion and release of neurotransmitter vesicles
What does IL-2 do?
proliferation and differentiation of helper T cells
stimulation of B cell division
activation of monocytes and natural killer cells
growth and INF gamma secretion of T cells
AchE in amniotic fluid
just like AFP– neural tube defects
Gq series of events
GDP swap for GTP Phospholipase C PIP2 --> DAG and IP3 increased protein kinase C increased Ca 2+
fluid filled cavity in liver and fever
underdeveloped country- parasite
developed- bacterial; likely staph by hematogenous spread
hemiballism
wild involuntary flinging of prox limbs on 1 side of body
damage to subthalamic nucleus
vasopressin causes decreased clearance of what
urea to concentrate in medulla
oseltamivir MOA
inhibit virion particle release
Wiskott Aldrich
excema, thrombocytopenia, infections
X-linked
bone marrow transplant
folate defish can be made up for with
thymidine (formation of dTMP)
aPTT vs PT
PT- extrinsic pathway, factor VII
aPTT- intrinsic pathway, factors XII, XI, IX, VIII
Rx absence seizures
ethosuximmide, or valproate
what makes elastin rubbery?
lysine crosslinks
insulin receptors
tyrosine kinase
Phosphatase
orotic aciduria
megaloblastic anemia
supplement with uridine
how do trycyclic ADs cause death?
inhibit fast Na+ channels –> cardiac arrhythmia
what do neurophysins do?
carry oxytocin and vasopressin
what process –> menstrual bleeding?
apoptosis
lots of raw egg whites–>
biotin deficiency
derm changes
decreased pyruvate carboxylase (pyruvate to oxaloacetate for gluconeogenesis)
parvovirus replicates where?
erythrocyte precursors in bone marrow
turner syndrome heart defect
bicuspid aortic valve
gonadal arteries arise from
abdominal aorta
tubular osmolarity in the absence of ADH is highest where?
bottom of the loop of henle
