comlex Flashcards

1
Q

Porphyria cutanea tarda. What enzyme is missing?

A
  • most common porphyria
    pohtosensitive –> blistering
    deficiency in uroporphyrinogen decarboxylase -> uroporphyrin accumulates in the urine
    exacerbated by alcohol
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2
Q

reciprocal inhibition

A

uses the reflex relaxation of the agonist muscle when the antagonist muscle is contracted

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3
Q

alkaptonuria

A

metabolic disorder –> black discoloration of cartilage, arthritis, and dark urine

caused by autosomal recessive deficiency of homogentisic acid oxidase

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4
Q

most congenital enzyme deficiencies inherited how?

A

autosomal recessive

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5
Q

methimazole complications

A

agranulocytosis –> increased infections

treatment for hyperthyroidism

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6
Q

what statistical test do we use for 2 groups with an interval variable?

A

t-test

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7
Q

periorbital cellulitis can –>

A

cavernous sinus thrombosis

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8
Q

achalasia

A

malfunction of the myenteric nerve plexus within the muscle of the esophagus –> no peristaltic wave

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9
Q

why does asthma get better with age?

A

airways increase in caliber

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10
Q

constrictive pericarditis

A

thickened, fibrotic pericardium
increased JVP, Kussmaul sign, rapid y descent, pericardial knock, hepatomegaly, ascites, fatigue, peripheral edema
causes: radiation, TB, infections, prior surgery, MI, pulmonary asbestosis, chronic renal failure, connective tissue disorders, neoplastic pericardial infiltration.

Transthoracic echocardiogram will show it

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11
Q

what do we give for tourettes?

A

haloperidol.

typical antipsychotics (haloperidol and fluphenazine) and atypical ones (risperidone, olanzapine, pimozide) decrease the severity of tics in Tourette syndrome.

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12
Q

psoas syndrome goes with

A

contralateral piriformis spasm
posterior sacral torsion
contralateral compensatory pelvic shift
ipsilateral pseudosciatica

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13
Q

how do we test if heparin is working well?

A

activated partial thromboplastin time

INR and prothrombin time are used for warfarin, etc.

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14
Q

ZES most common tumor site?

A

pancreas

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15
Q

waiter’s tip

A

= erb’s palsy

cervical roots C5 and C6

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16
Q

spondylolysis

A

defect in the pars interarticularis
scotty dog collar
caused by stress fracture, etc.

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17
Q

spondylitis

A

infection of the vertebra

18
Q

spondylolisthesis

A

anterior displacement of one vertebra in relation to the one below

19
Q

spondylosis

A

degenerative, usually osteoarthritic change in the shape of the vertebra (goes with degenerative disk changes)
squishing of nerve roots

20
Q

morning stiffness that improves with activity
narrowing of the joint spaces

dx?

A

rheumatoid arthritis

PANNUS FORMATION

21
Q

hepatitis virus families and features

A
A-  picorna, naked capsid
B- hepadnavirus, enveloped
C- flavivirus (RNA), enveloped (CHRONIC)
D- defective. Circular RNA, enveloped
E- Hepevirus, RNA, naked
22
Q

Sever disease

A

traction apophysitis of the calcaneus at the attachment of the Achilles tendon, causing pain in teh posterior aspect of the calcaneus. Related to overuse.

23
Q

determining if statistic (risk?) is significant (using confidence intervals)

A

Statistical signifance “rule of 1;” if 1.0 falls inside the presented interval, then we do not have significance.

24
Q

cocaine abuse during pregnancy–>

A

increased risk for placental abruption

25
Q

serologic markers for hep B

A

Anti-HBsAg - surface antigen : initially indicates active infection, continued presence indicates carrier state

IgM antibodies against HBc- core antigen- acute response to the pathogen and thus a recent infection

26
Q

most common cause of bacterial meningitis

A

strep pneumo

ppick neisseria for dormitories, extreely acute onset, presence of signs of endotoxin shock

27
Q

Vertebrobasilar insufficiency/ ischemia (VBI)

A

temporary symptoms caused by decreased blood flow to the posterior circulation of the brain
VERTIGO, drop attacks caused by leg weakness, dizziness, vision changes
can be provoked by sudden decreases in BP, postural changes, heat and dehydration, mechanical forces on the neck, turning the head to extreme angles or extending the neck

common in 7th, 8th decades. Males:females 2:1
atherosclerosis, HTN, diabetes, smoking, dyslipidemias- predisposing factors

28
Q

treat guillain barre with

A

IVIG

29
Q

eosinophilic pneumonitis, llymphadenopathy, and hepatosplenomegaly in the absence of ova or larvae

A

toxocara canis or cati

30
Q

pre-eclampsia vs eclampsia

A

preeclampsia- HTN with albuminuria, edema, abdominal pain

eclampsia- seizures or coma plus above

31
Q

Chapman point is caused by

A

viscerosomatic reflex

32
Q

normal CRI is

A

10-14 cycles per minute

33
Q

how to test for thoracic outlet syndrome

A

hyperabduction test

34
Q

layers of scrotum with testes

A

skin- skin
colles fascia and dartos muscle- superficial fascia
cremasteric fascia and muscle- internal oblique muxcle
internal spermatic fascia- transversalis fascia
extraperitoneal fat- extraperitoneal fat
tunica vaginalis- parietal

35
Q

treatment of status epilepticus

A

lorazepam

increases frequency of opening of GABA-associated chloride channels

36
Q

embryos develop limbs when?

A

4th gestational week

37
Q

episiotomy cuts what?

A

perineal body

38
Q

pigment bile stones goes with

A

sickle cell anemia and other hemolytic disease

39
Q

hidradenitis suppurativa

A

chronic follicular disease that occludes follicles, affecting nearby apocrine sweat glands
can occur anywhere apocrine sweat glands are abundant, but most frequently in the axilla and groin
axillary inflammation and fever are highly suggestive of the dx
rx can involve abx, antiandrogens, retinoids, surgery, or immune modulators

40
Q

2,3 DPG

A

byproduct of glycolysis
increases in COPD
–> right shift of the Hb-O2 dissociation curve, thus enhancing O2 unloading from Hb

41
Q

Broca’s area supplied by

A

middle cerebral artery

42
Q

meralgia paresthetica nerve

A

lat fem cutaneous