Uveitis Vol. 2

Question 1

What type of bacteria is associated with LPS endotoxin?

Answer 1

Gram-negative bacteria

Question 2

What protein is responsible for most of the inflammatory effects of LPS?

Answer 2

Lipid A

Question 3

What type of immune response is directed against LPS?

Answer 3

Innate immune response

Question 4

What is the major cause of shock, fever, and sepsis in gram-negative infections?

Answer 4

LPS

Question 5

What type of immune response is associated with Type I hypersensivity?

Answer 5

Anaphylactoid

Question 6

What type of immune response is associated with Type II hypersensivity?

Answer 6

Cytotoxic antibodies

Question 7

What type of immune response is associated with Type Ill hypersensivity?

Answer 7

Immune complex reactions

Question 8

What type of immune response is associated with Type IV hypersensivity?

Answer 8

Cell-mediated

Question 9

What type of immune response is associated with Type V hypersensivity?

Answer 9

Stimulatory

Question 10

What is function of the Fe portion of antibodies?

Answer 10

Attachment site of effector cells

Question 11

What are idiotopes?

Answer 11

Anitgenic sites on antibodies that other antibodies can bind to

Question 12

What are idiotypes?

Answer 12

Antibodies to idiotopes

Question 13

What is the most common immunoglobin found in the serum?

Answer 13

lgG

Question 14

What type of antibody crosses the placenta?

Answer 14

IgG

Question 15

What type of antibody is associated with mast-cell degranulation?

Answer 15

IgE

Question 16

What is a classic example of antibody complex binding that activates the complement cascade by the membrane attack complex?

Answer 16

Hemolytic anemia of the newborn (eg. due to Rh incompalibilty)

Question 17

What is the most commonly type of cancer associated with cancer-associated retinopathy?

Answer 17

Small-cell lung cancer

Question 18

What causes cancer-associated retinopathy?

Answer 18

Antibody mediated cross-reaction between tumor antigens and ocular autoantigens

Question 19

What is Goldmann-Witmer coefficient used to measure?

Answer 19

Ratio of intraocular localantibody production compared to serum antibody production

Question 20

What autoantigen is associated with Wegener granulomatosis?

Answer 20

Proteinase-3

Question 21

What is the function of IFN-gamma and TNF-B?

Answer 21

Activation of macrophages

Question 22

What type of cells are CD8 cytotoxic T-cells especially good at killing?

Answer 22

Tumor cells and virus infected cells

Question 23

What is the function of CD951igand (Fasl)?

Answer 23

Cell-programmed death (eg. apoptosis)

Question 24

What is primary type of immune reaction in sympathetic ophthalmia?

Answer 24

Th1 delayed-hypersensitivity response

Question 25

What autoantigens are thought to be responsible for sympathetic ophthalmia?

Answer 25

Retinal or uveal antigens

Question 26

What is the most frequent opportunistic ocular infection in patients with AIDS?

Answer 26

CMV

Question 27

What type of delayed hypersensitivity response is thought to play a role in allergic conjunctivitis?

Answer 27

Th2-mediated delayed hypersensitivity

Question 28

Which type of immunity typically activates the classical complement pathway?

Answer 28

Adaptive immunity

Question 29

Which type of immunity typically activates the alternative complement pathway?

Answer 29

Innate immunity

Question 30

What are the principal complement-derived immune mediators?

Answer 30

Anaphylatoxins

Question 31

What complement factor is responsible for opsonization?

Answer 31

C3b

Question 32

What is the primary role of the Hageman factor-dependent pathway?

Answer 32

Activation of kinins

Question 33

What enzyme is responsible for the activation of kinins?

Answer 33

Kallikrein

Question 34

What enzyme converts fibrinogen to fibrin?

Answer 34

Thrombin

Question 35

What enzyme is responsible for degradation of fibrin?

Answer 35

Plasmin

Question 36

What is the principle source of serotonin?

Answer 36

Platelets

Question 37

What two types of cells release histamine?

Answer 37

Mast cells and basophils

Question 38

What is the primary function of cyclooxygenase?

Answer 38

Conversion of arachidonic acid to PGG2

Question 39

What type of immune mediators are thought to play a role in cystoid macular edema associated with anterior segment surgery or trauma?

Answer 39

Prostaglandins