Pathology Volume 3 Flashcards

1
Q

What type of collagen is associated with Descemet’s membrane?

A

Type IV collagen

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2
Q

What is the most common inheritance pattern of CHED?

A

Autosomal recessive

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3
Q

What is the most common ocular association of sclerocornea?

A

Cornea planus

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4
Q

Of the classic corneal stromal dystrophies, which is autosomal recessive?

A

Macular dystrophy

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5
Q

What causes corneal whorls?

A

Deposition of lysosomal deposits within the basal layer of the epithelium

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6
Q

What chromosome is associated with macular dystrophy?

A

16q

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7
Q

What chromosome is associated with granular. Lattice and Avellino dystrophy?

A

5q

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8
Q

What causes corneal guttae?

A

Focal thickening of Descemet’s membrane

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9
Q

What condition is associated with PITX2 gene?

A

Axenfeld-Rieger syndrome

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10
Q

What is Axenfeld anomaly?

A

Posterior embryotoxon and iris adhesions to the cornea

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11
Q

What is Axenfeld syndrome?

A

Axenfeld anomaly plus glaucoma

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12
Q

What is Rieger anomaly?

A

Axenfeld anomaly plus iris atrophy

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13
Q

What is Rieger syndrome?

A

Rieger anomaly plus dental and skeletal abnormalities

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14
Q

What is thought to cause pigment dispersion syndrome?

A

Rubbing of the iris pigment epithelium by lens zonules

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15
Q

Name 3 systemic associations of exfoliation syndrome.

A
  1. Hypertension 2. Stroke 3. Myocardial infarction
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16
Q

What does angle recession represent histologically?

A

Tear in the ciliary body between the longitudinal and circular muscles

17
Q

Name 3 ocular complications of nanopthalmos.

A
  1. Hyperopia 2. Glaucoma 3.Uveal effusion syndrome
18
Q

Name the 3 layers of the sclera.

A
  1. Episcleral 2. Stroma 3. Lamina fusca
19
Q

What condition is associated with proliferation of spindle calls in a storiform pattern?

A

Fibrous histiocytoma

20
Q

How is the sclera altered in nanopthalmos?

A

Sclera is abnormally thick in nanopthalmos

21
Q

What is the most common location of senile calcific plaques?

A

Anterior to the lateral and medial rectus muscles

22
Q

What structures represent the tertiary vitreous?

A

Zonular fibers

23
Q

What does Bergmeister papilla represent?

A

Remnant of the posterior portion of the hyaloid artery

24
Q

What is the most common location of Mittendorf dot?

A

Inferonasal posterior capsule

25
Q

What disorder is associated with “candlewax drippings” of the retinal vasculature?

A

Sarcoidosis

26
Q

In what layer of the retina do cystic spaces occur in typical peripheral cystoid degeneration?

A

Outer plexiform layer

27
Q

In what layer of the retina do cystic spaces occur in reticular peripheral cystoid degeneration?

A

Nerve fiber layer

28
Q

What protein is associated with amyloid deposits of the vitreous?

A

Transthyretin

29
Q

What condition is associated with amyloid deposits of the vitreous?

A

Familial amyloid polyneuropathy

30
Q

What is the most common location of degenerative retinoschisis?

A

Inferotemporal

31
Q

Where does reticular peripheral cystoid degeneration occur?

A

Posterior to areas of typical peripheral cystoid degeneration

32
Q

What is the most common type of degenerative retinoschisis?

A

Reticular degenerative retinoschisis

33
Q

What causes the clinical appearance of cobblestone degeneration?

A

Adherence of the inner nuclear layer to Bruch’s membrane

34
Q

What do cytoid bodies represent?

A

Swollen NFL axons