uterus Flashcards
Describe the common functional endometrial disorders (causes of AUB and DUB) Describe acute and chronic endometritis and the common causes and clinical associations. Describe the proposed causes and complications of endometriosis Describe adenomyosis and its associated clinicopathologic findings Describe endometrial polyps (symptoms, causes, outcomes) Describe the endometrial hyperplasia / carcinoma sequence Describe the common malignant tumors of the endometrium (endometrioid, clear cell
bleeding due to alteration in the normal cyclical hormonal stimulation of the endometrium
dysfunctional uterine bleeding
causes of dysfunctional uterine bleeding
faiulre of ovulation
inadequate luteal phase
OCPs
menopausal changes
bleeding causes that are not considered dysfunctional uterine bleeding
polyp
hyperplasia/Carcinoma
endometriosis
causes of anovulatory cycles
excess estrogen
dysfunctional uterine bleeding associated with infertility and pregancy loss
inadequate luteal phase
dysfunctional uterine bleeding with low progesterone
inadequate luteal phase
endometriosis with neutrophils
acute
endometriosis with plasma cells
chronic
causes of acute endometriosis
birth, miscarrage, strep infection after retained products of conception
causes of chronic endometriosis
gonorrhea, chlamydia, IUD
most common locations of endometriosis
ovaries, pouch of douglas, peritoneal surfaces
likely cause of endometrosis
menstrual backflow through fallowian tubes
“chocolate cysts” and blood filled macrophages
endometriosis
growth of the endometrium into the mymetroum
adenomysosis
round muscular mass in uterus
adenomysosis
treatment for adenomysosis
hysterectomy
associated with tamifloxin
endometrial polyps
chance endometrial polyps develops into cancer
very very slight
time endometrial polyps develop
menopause most common
presents with abnormal postmenipausal bleeding
endometrial hyperplasia
endometrial hyperplasia with high risk of cancer
complex hyperplasia with atypia
cancer risk of complex hyperplasia with atypia
20-40%
histological sign of complex hyperplasia
atypical glands and more glands than stroma
most common female GU tract cancer
endometrial carcinoma
bigest risk for endometrial carcinoma
long term use of high-dose post menopausal estrogens
most commin presentation of endometrial carcinoma
post-menopausal bleeds
genetic mutation in endometrioid adenocarcinoma
PTEN
gebetic mutation in papillary carcinoma
p53
endometrial carcinoma automatically considered high grade
clear cell
pasmmomoa bodies
serous adenocarcinoma (epithelial)
adenocarcinoma of uterus spreads to
cervix
serous endometrial carcinoma spreads to
pevis and abdomen
treatment for adenocarcinoma of uterus
radiation
treatment for serous endometrial carcinoma
chemo
benign smooth muscle tumor of uterus
leimyoma
common name for leimyoma
fibroid
presentation of submucosal leiomyoma
menorrhagia
presentation of subserosal leiomyoma
constipation and urinary urgency
intersecting fascicles of begnin smooth muscle cells
leiomyoma
most common sarcoma of uterus
leiomyosarcoma
outcome for leiomyosarcoma
poor
microscopy of leiomyosarcoma
increased cellularity, mitotic figures, cogaulative necreosis