prostate Flashcards

Describe the zones of the prostate and the diseases that may be associated with each of them Describe the presentation and types of prostatic inflammation and how they may mimic malignancy Describe benign prostatic hyperplasia including its presentation and underlying pathologic process Describe the clinicopathologic features of prostate cancer and its precursor lesion (PIN) Be able to interpret PSA levels in regards to possible prostatic causes Describe the Gleason grading system for prost

1
Q

zone of prostate with most hyperplastic lesions

A

inner transition

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2
Q

zone of prostate with most carcinomas

A

peripheral zones

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3
Q

urinary obstructing benign lesions most likely orginates in

A

inner transition zone

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4
Q

most common type of prostatitis

A

chronic non bacterial/chronic pelvic pain syndrome

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5
Q

tender and boggy prostate on DRE with fever, chills and disuria

A

acute bacterial prostatitis

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6
Q

low back pain, dysuria, perineal/suprapubic discomfort

A

chronic bacterial/nonbacterial prostatitis

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7
Q

really is a pain in the ass to diagnose

A

chronic nonbacterial prostatsis

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8
Q

cause of BPH

A

androgen-dependant growth of stromal and glandular elements

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9
Q

chemical produced by prostate

A

dihydrotestosterone

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10
Q

drug type that can exacerbate BPH

A

alpha 1 adrenergic agonists

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11
Q

zone where BPH occurs

A

inner transitional zone

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12
Q

gross apperance of BPH

A

enlarged prostate with well-circumscribed solid or cystic nodules

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13
Q

secretory material in the glandular lumina produced by BPH

A

corpora amylacea

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14
Q

most common clinical manifestation of BPH

A

hesitancy and inturruption of the stream while voiding, urinary urgency, nocturia, incerased urinary frequency

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15
Q

ddx of BPH

A

urethral stricture or impaired bladder detrusor muscle

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16
Q

prostate cancer is what kind of tumor

A

adenocarcinoma

17
Q

prostate cancer is dependant on what for survival

A

androgens

18
Q

mutation common in prostate cancer as it progrosses

A

permits androgen receptors to activate the expression of the target genes even in the absence of the hormones

19
Q

common genes in prostate cancer

A

TMPRSS2-ETS

20
Q

signaling pathway activated in prostate cancer

A

Pi3K/AKT inactivating PTEN

21
Q

gene that may lead to more prostate caner in blacks

A

MYC on 8q24

22
Q

gross morphology of prostate cancer

A

more solid whitish mass than the spongy normal stroma

23
Q

prostatic cancer grading system

A

gleason

24
Q

how to use gleason grading system

A

addisn the primary and secondary patterns 1-5 value and add (1 for well-differentated, 5 for no glandular differentiaion)

25
Q

DRE exam finding with prostate cancer

A

irregular hard nodule

26
Q

pattern of spread of prostate cancer

A

seminal vesciles, wall of urinary bladder, to rectum, advacing to axial skeleton

27
Q

level of PSA considered abnormal

A

generally 4

28
Q

PSA finding more indicitive of cancer

A

ratio of free PSA to total PSA

29
Q

may to assess prostate cancer therapy response

A

change in PSA