STI 1 Flashcards
Diagnose gonorrhea based on presentation and clinical lab results. Treat newborn ocular infections with Neisseria. Describe chlamydial morphology and pathogenesis.
acute anterior utheritis with painful urinationm and urerthral discharge.
gonorrhea
vaginal discharge, dysuria, bleeding
gonorrhea
anal discharge and bleeding
anal gonorrhea
morphology of N gonorrhoeae
gram negative diplococci resembling a kidney bean
presumptive diagnosis of N gonorrhoeae
gram - (good enough for guys) and colonies turn black on oxidative reagent (needed for females)
virulence factors of N gonorrhoeae
protein I/Opa protein LOS antigenic variation ohase shift IgA protease
N gonorrhoeae virulence factor respinsible for most symptoms
LOS
pustular skin lesions, septic arthritis,
disseminated gonococcal infection
treatment of neisseria newborn eyes
profylaxis antibiotics
potential complication of N gonorrhoeae in women
PID—> endometritis/salphinitis/peritonitis –> tubal obstruction/ectopic pregnancy
stain for chlamydia
giemsa stain
outer membrane structures NOT in chlamydia
peptidiglycan or muramic acid
stage chlymadia is taken up by the cell
infectious stage/elementary body
group of chlamydia within a vacoule
inclusion body
major cause of preventable blindness in the world
C trachomatis
pathenogenisis of trachoma
chronic and repeated infection results in scarring of conjunctiva
scar tissue from the delayed hypersensitivity response causes distortion of eyelids so that eyelashes abrade cornea
inflammation of cornea neovascularization scars cornea (pannus) resulting in permanant blindness
vector of trachoma
flies
self liminting trachoma conjunctives
inclusion conjunctivitis
trachoma type common in US
inclusion conjunctivitis
most common STI in US
genital chlamydia
pathogenisis of genital chlamydia
orginisms bind to toll receptors which elicit translocation of NFkB in host cell. This effects production of IL-1 and IL-8.
causes the damage of genital chlamydia
acute inflamatory response of PMN in epithelium and mononuclear cells in submucosa
most cases are asymptomatic
genital chlamydia
causes reiter’s disease
genital chlamydia
diagnosis of genital chlamydia
ampflication of DNA or RNA
what must be gotten to culture genital chlamydia
cells from urethra or cervix
most common neonate genital chlamydia infection
inclusion conjunctivitis
diagnosis of neonate chylmidia conjunctivitis
culture or giesma stain
diagnosis of chymida pneumonitis
high titer of IgM atnibody
chlymidia infection in homosexuals
lymphogranuloma venerum
shallow ulcer or papule on genitalis
lymphogranuloma venerum
can cause rectal strictures of elephantitis
lymphogranuloma venerum
