URTI Flashcards

1
Q

Acute Bronchitis – Pathogens and Clinical Presentation

Most common pathogens
- respiratory ___

Clinical presentations
- cough
- sore throat
- ___ (runny/stuffy nose, sneezing, post-nasal drip)
- malaise
- headache
- ___
- normal chest imaging

A
  • viruses
  • coryza
  • fever
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2
Q

Acute Bronchitis – Treatment

Treatment
- ___
- Symptomatic management
- Corticosteroids not necessary
- Antibiotic therapy not necessary (please!)

Methods to reduce antibiotic prescribing
- Delayed antibiotic prescribing
- Show empathy/listen to patient
- Provide patient education on duration of illness (up to 2-3 weeks)
- Provide patient education on the futility of antibiotic therapy
- Discuss treatment plan with symptomatic management
- Use terms related to viral infection when discussing with patient

Number needed to harm: ___ pts

A
  • Self-limiting
  • 5
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3
Q

Acute Exacerbation of Chronic Bronchitis – Clinical Presentation

Established diagnosis of chronic bronchitis
- Chronic cough with productive sputum on most days for ≥ 3 consecutive months for __ consecutive years

Hallmark signs of acute exacerbation
▪Increased sputum ___
▪Increased sputum ___
▪Increased ___ or ___

A
  • 2
  • purulence
  • volume
  • cough, SOB
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4
Q

Acute Exacerbation of Chronic Bronchitis – Pathogens

Most common organisms (3)

Patients with frequent antibiotic use (2)

A

Most common:
- Streptococcus pneumoniae
- Haemophilus influenzae
- Moraxella catarrhalis

Frequent Abx Use:
- Enterobacterales
- Pseudomonas aeruginosa

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5
Q

Acute Exacerbation of Chronic Bronchitis – Treatment

Preferred Treatment Options
- ___ 875/125 mg PO q12h
- ___ 500 mg PO q12h
- ___ 200 mg PO q12h

Treatment Duration: __ - __ days

A
  • Amoxicillin/clavulanate
  • Cefuroxime
  • Cefpodoxime

5-7

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6
Q

Acute Exacerbation of Chronic Bronchitis – Treatment

Alternative Treatment Options
- ___ 100 mg PO q12h
- ___ / ___ 1 DS PO q12h
- ____ 500 mg PO day 1, then 250 mg daily on days 2-5

Risk for P. aeruginosa
- ___ 750 mg PO daily

A
  • Doxycycline
  • TMP/SMX
  • azithromycin
  • levofloxacin
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7
Q

Acute Pharyngitis – Pathogens and Considerations

Most common pathogens
- Respiratory ___ – rhinovirus, coronavirus, adenovirus most common
- Bacteria – Streptococcus ___ (group A)

Concern for complications with bacterial cause
- Rheumatic ___
- Glomerulonephritis
- Peritonsillar or retropharyngeal abscess
- Mastoiditis
- Otitis media
- Rhinosinusitis

A
  • viruses
  • pyogenes
  • fever
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8
Q

Acute Pharyngitis – Clinical Presentation

  • Sudden onset of ___ ___ with dysphagia and fever
  • Pharyngeal hyperemia and ___ swelling (may have exudates)
  • Enlarged, tender lymph nodes
  • Red, swollen ___
  • Petechiae on soft palate
A
  • sore throat
  • tonsillar
  • uvula
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9
Q

Acute Pharyngitis – Testing

Historically, culture of the throat was the diagnostic standard
- Limitation – takes __ - __ hours to return

Rapid antigen detection tests (RADT) have gained popularity
- Limitation – sensitivity 70-90% compared to culture (chance for false-negative)

Back up testing with ___ or ___ based test needed if RADT negative

A
  • 24-48
  • culture, PCR
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10
Q

Acute Pharyngitis – Treatment

Targeted treatment for Streptococcus pyogenes (Group A)
- ___ ___ 250 mg PO TID - QID or 500 mg PO BID x __ days
- ___ 500 mg PO TID or 875 mg PO BID x __ days

A
  • penicillin VK, 10
  • amoxicillin, 10
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11
Q

Acute Pharyngitis – Treatment

Alternatives if penicillin allergy
Non-anaphylactic reaction
- ___ 500 mg PO BID x 10 days
- ___ 500 mg PO BID or 1 gram PO once daily x 10 days
- ___ 500 mg PO BID x 10 days
- ___ 200 mg PO BID x 5-10 days

Anaphylactic reaction
- ___ 500 mg PO on day 1, then 250 mg PO daily on days 2-5
- ___ 300 mg PO TID x 10 days

A

Non-anaphylactic
- cephalexin
- cefadroxil
- cefuroxine
- cefpodoxime

Anaphylactic
- azithromycin
- clindamycin

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12
Q

Acute Bacterial Rhinosinusitis – Common Terms

Acute rhinosinusitis
- ___ nasal drainage
- nasal obstruction, facial pain/ ___
- may last ≥ __ weeks

A
  • purulent
  • pressure
  • 4
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13
Q

Acute Bacterial Rhinosinusitis – Common Terms

Viral rhinosinusitis
- Acute rhinosinusitis thought to be due to viral pathogen
- Symptoms present < ___ days, not worsening

A
  • 10
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14
Q

Acute Bacterial Rhinosinusitis – Common Terms

Acute bacterial rhinosinusitis (ABRS)
- Acute rhinosinusitis thought to be due to bacterial pathogen
- Persistent symptoms ≥ ___ days with no improvement
- Severe symptoms – ___ , purulent nasal discharge, facial ___ for 3-4 consecutive days at beginning of illness
- Worsening symptoms – new onset of symptoms after initial improvement in symptoms

A
  • 10
  • fever, pain
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15
Q

Acute Bacterial Rhinosinusitis – Common Terms

Recurrent acute rhinosinusitis
- ___ or more episodes of ABRS per year

A

4

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16
Q

Acute Bacterial Rhinosinusitis – Common Terms

Chronic rhinosinusitis
- ≥ 2 signs/symptoms for ___ weeks or longer

17
Q

Acute Bacterial Rhinosinusitis – Pathogenesis

1) ___ upper respiratory tract infection - mucosal inflammation
2) ___ sinus drainage - Mucosal secretions trapped
3) ___ bacteria proliferate - Bacterial infection established

A

1) viral
2) decreased
3) local

18
Q

Acute Bacterial Rhinosinusitis – Common Pathogens

Most common pathogens similar to other respiratory infections (3)

Additional pathogens in patients with frequent antibiotic use (2)

A

Most common
- Streptococcus pneumoniae
- Haemophilus influenzae
- Moraxella catarrhalis

Additional pathogens in pts with frequent Abx use
- Staphylococcus aureus (MSSA, MRSA)
- Pseudomonas aeruginosa

19
Q

Acute Bacterial Rhinosinusitis – Clinical Presentation

Major Symptoms

A
  • Purulent anterior and/or posterior nasal
    discharge
  • Nasal congestions and obstruction
  • Facial congestion and fullness
  • Facial pain and pressure
  • Hyposmia or anosmia
  • Fever
20
Q

Acute Bacterial Rhinosinusitis – Clinical Presentation

Minor Symptoms

A
  • headache
  • ear pain, pressure, or fullness
  • halitosis
  • dental pain
  • cough
  • fatigue
21
Q

Acute Bacterial Rhinosinusitis – Diagnostic Consideration

Clinical presentation with symptoms suggestive of ABRS
- ___ symptoms
- ___ symptoms
- ___ symptoms (after initial improvement)

Sinus radiograph or CT scan

Culture from nasal secretions or cavity

Sinus puncture and culture (ouch!)

A
  • persistent
  • severe
  • worsening
22
Q

Acute Bacterial Rhinosinusitis – Treatment

Two approaches to ABRS treatment
1. Initiate antibiotic therapy as soon as bacterial infection established
2. Watchful waiting up to __ days to observe if improvement occurs without antibiotic therapy

First-line treatment options
- ___ / ___ 500/125 mg PO TID or 875/125 mg PO BID x 5-7 days
- ___ / ___ 2000/125 mg PO BID if concern for penicillin resistance x 5-7 days

Second-line treatment options
▪___ 100 mg PO BID x 5-7 days
▪___ 500 mg PO once daily x 5-7 days
▪___ 400 mg PO once daily x 5-7 days

A
  • 7
  • Amoxicillin/clavulanate, Amoxicillin/clavulanate
  • doxycycline
  • levofloxacin
  • moxifloxacin
23
Q

T or F
Oral 2nd and 3rd generation cephalosporins, macrolides, and TMP/SMX are used in the treatment of Acute Bacterial Rhinosinusitis

A

FALSE
not
recommended due to concern
for S. pneumoniae resistance

24
Q

Acute Bacterial Rhinosinusitis – Treatment

Concern for MRSA
- Add agent with MRSA coverage (e.g., ___ , ___ , ___ , clindamycin?)
- Maintain coverage for common organisms unless cultures suggest ___ infection with MRSA

Concern for P. aeruginosa
- ___ – consider higher dose with 750 mg PO daily
- Maintain coverage for common organisms unless cultures suggest ___ infection with P. aeruginosa

A
  • doxycycline, TMP/SMX, linezolid
  • monomicrobial
  • levofloxacin
  • monomicrobial
25
Q

Acute Bacterial Rhinosinusitis – Supportive Care

  • Intranasal saline irrigation
  • Warm facial packs
  • NSAIDs and/or acetaminophen
  • Maintain ___ – thin secretions
  • Avoid ___ – thickens mucus, more difficult to clear
  • Caution with ___ – concern for rebound congestion
A
  • hydration
  • antihistamines
  • decongestants