Urology: Prostatic Cancer Flashcards

1
Q

what can be found superior to the prostate?

A

neck of the bladder

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2
Q

what can be found inferior to the prostate?

A

external urethral sphincter

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3
Q

which muscle can be found inferlaterally to the gland?

A

levator ani

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4
Q

what can be found posterior to the gland?

A

ampulla of the rectum

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5
Q

what does the prostate secrete?

A

proteinlytic enzymes

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6
Q

where do the prostatic ducts open?

A

prostatic portion of the urethra on each side of the seminal colliculus

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7
Q

3 zones of the prostate

A
  • central zone
  • transitional zone
  • peripheral zone
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8
Q

what happens at the central zone?

A
  • it surrounds the ejaculatory ducts

- the ducts of the glands from the zone empty obliquely into the prostatic urethra

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9
Q

what happens at the transitional zone?

A
  • surrounds the urethra

- these are the glands that traditionally are involved in BPH

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10
Q

what happens at the peripheral zone?

A
  • ducts from this area empty vertically which can permit urine reflux
  • this is the zone that can be felt in a DRE
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11
Q

what is the fibromuscular stroma?

A
  • situated anteriorly in the gland

- merges with the tissue of the urogenital diaphragm

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12
Q

how is the prostate vascularised?

A
  • prostatic arteries (from the internal iliac arteries)

- prostatic venous plexus, draining into the internal iliac vein

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13
Q

how is the prostate innervated?

A

the inferior hypogastric plexus supplies sympathetic, parasympathetic and sensory innervation
- the smooth muscle is innervated by the sympathetic fibres

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14
Q

why are the neighbouring neurovascular bundles important?

A
  • these go to the penis, to supply blood and innervation to the corpora cavernose, which are important for a normal erection
  • these might be damaged during radical prostatectomy
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15
Q

what is the most common type of prostate cancer?

A

adenocarcinoma

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16
Q

risk factors for prostate cancer

A
  • age
  • family history
  • ethnicity
17
Q

how can prostate cancer spread?

A
  • local
  • lymph
  • haematogenous
18
Q

symptoms of prostate cancer

A
  • mainly asymptomatic
  • urinary frequency
  • low flow
  • urgency
  • haematuria
  • obstructive symptoms, irritative symptoms, bleeding and haematospermia
  • uraemia
  • advanced disease: anaemia, bone pain, renal failure, weight loss, anorexia
19
Q

causes of high PSA

A
  • old age
  • BPH
  • prostate CA
  • prostatitis
  • instrumentation
  • acute urinary retention
  • prostatic stimulation
20
Q

investigations of prostate cancer

A
  • PSA assays
  • CBC
  • creatinine
  • LFTs (alkaline phosphate)
  • transrectal ultrasound
  • MRI prostate to stage and detect the cancer
  • CT abdo
  • bone scan
  • LN staging at surgery
  • MRI/US fusion biopsy
21
Q

what staging classification do you use?

A

TNM classification and Gleason score

22
Q

what can determine and contribute to prognosis?

A
  • tumour stage
  • Gleason grade
  • PSA at diagnosis
  • tumour volume
  • capsular penetration, seminal vesicle invasion or margin positivity at the time of prostatectomy
  • patient factors also important - age, co-morbidity
23
Q

treatment options for prostate cancer

A
  • active surveillance (monitor PSA)
  • external beam radiotherapy
  • radical prostatectomy
  • depends on your age (younger patients will get more aggressive treatment)
  • brachytherapy (seeds of radiotherapy implanted into the prostate)
  • hormonal therapy (block testosterone production)
24
Q

what should you do after treatment

A

continue monitoring the PSA level

25
Q

treatment options for relapsed cancer

A
  • salvage radiotherapy
  • salvage radical prostatectomy
  • hormonal therapy
26
Q

treatment options for advanced disease

A
  • hormonal manipulation
  • medical/surgical castration - subcapsular orchidectomy, LHRH agonists, LHRH antagonists
  • testoterone flare - cover with anti-androgens
27
Q

causes of an increased PSA level

A
  • infection
  • instrumentation
  • benign and malignant prostate condition
28
Q

how does contrast interact with prostatic cells?

A

cancer cells are packed in a tighter way which result in less diffusion and pools at a certain area

29
Q

complications of external beam radiotherapy

A
  • urinary side effects (frequency, urgency)

- rectal side effects (diarrhoea, pain on defaecation, rectal bleeding)

30
Q

which blood test is a good predictor for bone metastasis

A

PSA (>20 more likely to have metastasis)

31
Q

types of hormonal therapy

A
  • androgen ablation (surgical/medical castration)
  • anti-androgen
  • oestrogen