Urology / Gi

Question 1

Ondansetron / Zofran

Answer 1

Classification
Antiemetic

MOA
Antiemetic and a selective 5-ht3 receptor antagonist used for nausea and vomiting

Indications
Nausea, vomiting

Contraindications
Hypersensitivity

Dosage/ Route of administration
4-8 mg PO IM IV

Question 2

Metoclopramide / Reglan

Answer 2

Classification
Antiemetic

MOA
Sensitizes tissues to acetylcholine stimulating upper GI tract motility (contractions) antagonizes dopamine receptors producing antiemetic (Helps nausea) effects

Indication
Nausea, vomiting, small intestine intubation, gastroparesis

Contraindications
Hypersensitivity, GI bleed, GI obstruction, pheochromocytoma, Hemorrhage, bowel obstruction

Dosage/ Route of administration
Nausea, vomiting 1-2 mg/kg IV

Small bowel Intubation 10mg IV

GERD 10-20 mg PO,IM,IV

Question 3

Prochlorperazine / Compro

Answer 3

Classification
Antiemetic, Antipsychotic

MOA
Blocks D2 receptors Used to treat schizophrenia and anxiety as well as control severe nausea and vomiting

Indication
Anxiety, Schizophrenia, Nausea, Vomiting, Vertigo

Contraindication
Hypersensitivity, Coma, in presence of CNS depressants, pediatric surgeries, children under 2 years old Dementia

Dosage
Nausea vomiting 5-10 mg IV,IM

Anxiety 5 mg IV, IM

Schizophrenia 5-10 mg IV,IM

Question 4

Promethazine / phenergan

Answer 4

Classification
Antihistamine

MOA
Blocks the histamine receptor used to treat allergies and can also be used for sedation for pre and post medical procedures

Indications
Motion sickness, allergic reactions, Nausea, vomiting, Urticaria

Contraindications
Hypersensitivity, Coma

Dosage/ Route of administration
Allergic reaction, Urticaria 25 mg PO

Motion sickness 25 mg PO

Nausea Vomiting 12.5-25 mg PO,IM,IV

Sedation 25-50 IV,IM