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Renal II Exam 1 > Urogenital Disorders - 9/13 Fitzpatrick > Flashcards

Urogenital Disorders - 9/13 Fitzpatrick Flashcards

1
Q

What converts androstenedione to estrone?

A

Aromatase

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2
Q

What drug blocks CYP17 and is used to treat advanced prostate cancer?

A

Abiraterone

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3
Q

What adverse side effects are caused by initial GnRH surge?

A

Bone pain

Spinal cord pain or paralysis

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4
Q

Side effects of Abiraterone?

A

Cortisol deprivation

Aldosterone accumulation

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5
Q

What converts estrone to estradiol?

A

17Beta-hydroxylase

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6
Q

What drug causes circulating testosterone to surge initially and then drop later?

A

Leuprolide

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7
Q

What converts estrone to estradiol?

A

17Beta-hydroxylase

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8
Q

What converts androstenedione to testosterone?

A

17Beta-hydroxylase

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9
Q

What drug is used to treat men with advanced prostate cancer but has significant hepatotoxicity?

A

Ketoconazole

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10
Q

What hormone is administered in infertile men which stimulates Leydig cells to secrete testosterone?

A

hCG

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11
Q

What is the typical GnRH agonist?

A

Leuprolide

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12
Q

What converts testosterone to estradiol?

A

Aromatase

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13
Q

What converts testosterone to estradiol?

A

Aromatase

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14
Q

What causes secondary hypogonadism infertility?

A 
Exogenous androgens
Anabolic steroids (andro and T overexposure)

Taken in a NON-pulsatile form

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15
Q

What converts testosterone to estradiol?

Located where?

A

Aromatase

Sertoli cells

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16
Q

FSH stimulates what?

Needs what else?

A

Sertoli cells

Testosterone

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17
Q

What converts testosterone to estradiol?

Located where?

A

Aromatase

Sertoli cells

18
Q

What androgen receptor antagonist is used in combination with surgical castration?

A

Nilutamide

19
Q

What converts testosterone to dihydrotestosterone (DHT)?

A

Steroid 5alpha reductase

20
Q

What is the typical natural GnRH?

A

Gonadorelin

21
Q

What drug is used to treat men with advanced prostate cancer but has significant hepatotoxicity?

A

Ketoconazole

22
Q

What is the typical natural GnRH?

A

Gonadorelin

23
Q

What androgen receptor antagonist is used with Leuprolide?

Taken how often?

A

Bicalutamide

Qd

24
Q

What converts androstenedione to estrone?

A

Aromatase

25
Q

What drugs are Aromatase inhibitors?

A

Anastrazole

Letrazole

26
Q

What precursor substance it’s converted to DHEA?

A

Pregnenolone

27
Q

What converts androstenedione to testosterone?

A

17Beta-hydroxylase

28
Q

What drugs are Aromatase inhibitors?

A

Anastrazole

Letrazole

29
Q

What causes secondary hypogonadism infertility?

A 
Exogenous androgens
Anabolic steroids (andro and T overexposure)

Taken in a NON-pulsatile form

30
Q

LH stimulates what?

To make what?

A

Leydig cells

Testosterone

31
Q

What is the typical GnRH antagonist?

A

Degarelix

32
Q

What drug causes circulating testosterone to surge initially and then drop later?

A

Leuprolide

33
Q

What androgen receptor antagonist is used with General GnRH agonists?

Taken how often?

A

Flutamide

Tid

34
Q

Is Degarelix slow or fast acting?

A

Fast acting (within 2-3 days)

35
Q

What drug blocks CYP17 and is used to treat advanced prostate cancer?

A

Abiraterone

36
Q

What converts testosterone to dihydrotestosterone (DHT)?

A

Steroid 5alpha reductase

37
Q

What precursor substrate is converted to Androstenedione?

A

Progesterone

38
Q

What drug is a selective estrogen receptor modulator (SERM)?

Acts as a what?

A

Clomiphene

Estrogen receptor antagonist

39
Q

Abiraterone is almost always used in combination with what?

A

Prednisone or other corticosteroids

40
Q

What drug is a selective estrogen receptor modulator (SERM)?

Acts as a what?

A

Clomiphene

Estrogen receptor antagonist

41
Q

Side effects of Abiraterone?

A

Cortisol deprivation

Aldosterone accumulation

42
Q

What has an adverse side effect of increased levels of liver enzymes on lab tests?

A

Degarelix

Renal II Exam 1 (6 decks)

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