Urogenital Disorders - 9/13 Fitzpatrick

Question 1

What converts androstenedione to estrone?

Answer 1

Aromatase

Question 2

What drug blocks CYP17 and is used to treat advanced prostate cancer?

Answer 2

Abiraterone

Question 3

What adverse side effects are caused by initial GnRH surge?

Answer 3

Bone pain

Spinal cord pain or paralysis

Question 4

Side effects of Abiraterone?

Answer 4

Cortisol deprivation

Aldosterone accumulation

Question 5

What converts estrone to estradiol?

Answer 5

17Beta-hydroxylase

Question 6

What drug causes circulating testosterone to surge initially and then drop later?

Answer 6

Leuprolide

Question 7

What converts estrone to estradiol?

Answer 7

17Beta-hydroxylase

Question 8

What converts androstenedione to testosterone?

Answer 8

17Beta-hydroxylase

Question 9

What drug is used to treat men with advanced prostate cancer but has significant hepatotoxicity?

Answer 9

Ketoconazole

Question 10

What hormone is administered in infertile men which stimulates Leydig cells to secrete testosterone?

Answer 10

hCG

Question 11

What is the typical GnRH agonist?

Answer 11

Leuprolide

Question 12

What converts testosterone to estradiol?

Answer 12

Aromatase

Question 13

What converts testosterone to estradiol?

Answer 13

Aromatase

Question 14

What causes secondary hypogonadism infertility?

Answer 14

Exogenous androgens
Anabolic steroids (andro and T overexposure)

Taken in a NON-pulsatile form

Question 15

What converts testosterone to estradiol?

Located where?

Answer 15

Aromatase

Sertoli cells

Question 16

FSH stimulates what?

Needs what else?

Answer 16

Sertoli cells

Testosterone

Question 17

What converts testosterone to estradiol?

Located where?

Answer 17

Aromatase

Sertoli cells

Question 18

What androgen receptor antagonist is used in combination with surgical castration?

Answer 18

Nilutamide

Question 19

What converts testosterone to dihydrotestosterone (DHT)?

Answer 19

Steroid 5alpha reductase

Question 20

What is the typical natural GnRH?

Answer 20

Gonadorelin

Question 21

What drug is used to treat men with advanced prostate cancer but has significant hepatotoxicity?

Answer 21

Ketoconazole

Question 22

What is the typical natural GnRH?

Answer 22

Gonadorelin

Question 23

What androgen receptor antagonist is used with Leuprolide?

Taken how often?

Answer 23

Bicalutamide

Qd

Question 24

What converts androstenedione to estrone?

Answer 24

Aromatase

Question 25

What drugs are Aromatase inhibitors?

Answer 25

Anastrazole | Letrazole

Question 26

What precursor substance it's converted to DHEA?

Answer 26

Pregnenolone

Question 27

What converts androstenedione to testosterone?

Answer 27

17Beta-hydroxylase

Question 28

What drugs are Aromatase inhibitors?

Answer 28

Anastrazole | Letrazole

Question 29

What causes secondary hypogonadism infertility?

Answer 29

``` Exogenous androgens Anabolic steroids (andro and T overexposure) ``` Taken in a NON-pulsatile form

Question 30

LH stimulates what? To make what?

Answer 30

Leydig cells Testosterone

Question 31

What is the typical GnRH antagonist?

Answer 31

Degarelix

Question 32

What drug causes circulating testosterone to surge initially and then drop later?

Answer 32

Leuprolide

Question 33

What androgen receptor antagonist is used with General GnRH agonists? Taken how often?

Answer 33

Flutamide Tid

Question 34

Is Degarelix slow or fast acting?

Answer 34

Fast acting (within 2-3 days)

Question 35

What drug blocks CYP17 and is used to treat advanced prostate cancer?

Answer 35

Abiraterone

Question 36

What converts testosterone to dihydrotestosterone (DHT)?

Answer 36

Steroid 5alpha reductase

Question 37

What precursor substrate is converted to Androstenedione?

Answer 37

Progesterone

Question 38

What drug is a selective estrogen receptor modulator (SERM)? Acts as a what?

Answer 38

Clomiphene Estrogen receptor antagonist

Question 39

Abiraterone is almost always used in combination with what?

Answer 39

Prednisone or other corticosteroids

Question 40

What drug is a selective estrogen receptor modulator (SERM)? Acts as a what?

Answer 40

Clomiphene Estrogen receptor antagonist

Question 41

Side effects of Abiraterone?

Answer 41

Cortisol deprivation | Aldosterone accumulation

Question 42

What has an adverse side effect of increased levels of liver enzymes on lab tests?

Answer 42

Degarelix