Puthoff Lecture 3 Flashcards
Inheritance of adult polycystic kidney disease?
Autosomal dominant
What does mahogany-brown and well-circumscribed with central stellate scar and large morphology describe?
Renal oncocytoma
Which form of ARPKD (children) is being described?
20% CDs cystic, hepatic fibrosis, portal HTN, die in early childhood?
Infantile
What subclass of RCC has papillary growth pattern, trisomy of 7 (loss of MET), 16, 17, loss of Y?
Prognosis?
Papillary carcinoma
Better
Inheritance pattern for Nephronopthisis Familial form?
Autosomal recessive
What are the extra-renal manifestations associated with ADPKD?
40% hepatic cysts
4-10% DIE of subarachnoid hemorrhage
25% mitral valve prolapse
82% diverticular disease
What tumor occurs in mostly men, around 60-80 y/o and has cigarette smoking, HTN, obesity, and TS ask RFs?
RCC
Which form of ARPKD (children) is being described?
Less than 10% CDs, cystic, most do not survive past adolescence
Juvenile
What genetics are associated with renal papillary adenoma?
Trisomy 7 and 17
Wilms tumor tri phasic pattern composed of what?
Stromal
Epithelial
Blastemal
What is the classic triad of Sx for RCC?
Hematuria
CVA pain
Palpable flank mass
Renal oncocytomas arise from what?
Present when?
Type A intercalated cells
Adulthood
Composition of most common type of kidney stone?
Calcium oxalate and phosphate
Xp11 translocation carcinoma has what gene translocation?
TFE3
What cancers metastasize TO the kidney?
Lung, melanoma, breast, GI, pancreas
What are the most common subtypes of autosomal recessive polycystic kidney disease?
Perinatal
Neonatal
What group of diseases is the most common genetic cause of ESRD in children and young adults?
Nephronopthisis
Order of most common childhood malignant tumors?
- Acute leukemia
- Neuroblastoma
- Retinoblastoma
- WILMS TUMOR