Male Disorders - 9/7 Fitzpatrick Flashcards
What drug should be avoided in hepatic impairment?
Alfuzosin
Which PDE I has selectivity for the retina?
What drugs act here?
What adverse side effect?
6
Sildenafil, vardenafil
Blue vision disturbance
Which SAR inhibitor is specific?
For what?
Finasteride
SAR II
Prostate alpha subtype receptor?
Alpha-1 A
Alpha 1A receptors + NE = what?
Muscle contraction
Hypertrophic prostate has excess what?
Steroid 5alpha-reductase (SAR) type II
How does NO cause smooth muscle relaxation?
Activates guanylate cyclase -> cGMP
What breaks down cAMP?
PDE-2, 3, 4
What do PDE-5 I’s inhibit?
Name them
cGMP breakdown
Sildenafil
Vardenafil
Tadalafil
Which PDE-5I should be taken on an empty stomach?
Sildenafil
Vardenafil
Terazosin and Doxazosin have what adverse effects?
Uroselective?
Drug interaction?
Postural hypotension
NO
PDE-5 inhibitors
What are the adverse effects of SAR inhibitors?
ED
Gynecomastia
Dec libido
Ejaculation disturbance
How are PDE-5I’s cleared?
hepatic CYP 3A4
How does caverject and PGE2 work?
Activates cAMP
What are the adverse effects of Tamsulosin and Silodosin?
Drug interaction?
Reduced ejaculation
Floppy iris syndrome (IFIS)
Cyp450