Male Disorders - 9/7 Fitzpatrick Flashcards

1
Q

What drug should be avoided in hepatic impairment?

A

Alfuzosin

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2
Q

Which PDE I has selectivity for the retina?

What drugs act here?

What adverse side effect?

A

6

Sildenafil, vardenafil

Blue vision disturbance

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3
Q

Which SAR inhibitor is specific?

For what?

A

Finasteride

SAR II

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4
Q

Prostate alpha subtype receptor?

A

Alpha-1 A

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5
Q

Alpha 1A receptors + NE = what?

A

Muscle contraction

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6
Q

Hypertrophic prostate has excess what?

A

Steroid 5alpha-reductase (SAR) type II

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7
Q

How does NO cause smooth muscle relaxation?

A

Activates guanylate cyclase -> cGMP

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8
Q

What breaks down cAMP?

A

PDE-2, 3, 4

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9
Q

What do PDE-5 I’s inhibit?

Name them

A

cGMP breakdown

Sildenafil
Vardenafil
Tadalafil

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10
Q

Which PDE-5I should be taken on an empty stomach?

A

Sildenafil

Vardenafil

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11
Q

Terazosin and Doxazosin have what adverse effects?

Uroselective?

Drug interaction?

A

Postural hypotension

NO

PDE-5 inhibitors

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12
Q

What are the adverse effects of SAR inhibitors?

A

ED
Gynecomastia
Dec libido
Ejaculation disturbance

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13
Q

How are PDE-5I’s cleared?

A

hepatic CYP 3A4

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14
Q

How does caverject and PGE2 work?

A

Activates cAMP

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15
Q

What are the adverse effects of Tamsulosin and Silodosin?

Drug interaction?

A

Reduced ejaculation
Floppy iris syndrome (IFIS)

Cyp450

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16
Q

What is the main contraindication of PDE-Is?

A

Organic nitrates (for chest pain)

17
Q

PDE-5I have what adverse side effects?

A

Headache
Dyspepsia
Nasal congestion

18
Q

Caverject injects what substances to cause vasodilation and erection?

A

PGE2
Papaverine
Phentolamine

19
Q

Which drug is non-specific for alpha 1 subtypes?

A

Alfuzosin

20
Q

Which PDE-I is not recommended to be use for BPH with alpha 1-blockers?

A

Tadalafil

21
Q

Alpha 1D receptors + NE = what?

A

Detrusor instability

22
Q

Detrusor alpha subtype receptor?

A

Alpha 1D > alpha 1A

23
Q

What are the alpha 1 antagonists used to treat LUTS?

A

Da TATS

Doxazosin
Terazosin
Afluzosin
Tamsulosin
Silodosin
24
Q

What drug causes the side effects of back pain, myalgia, and lim pain?

Treatment?

A

Tadalafil

NSAID

25
Q

Spinal Cord alpha subtype receptor?

A

alpha 1D

26
Q

Which SAR decreases serum DHT more?

A

Dutasteride

27
Q

Which PDE I has selectivity for the corpus cavernosum?

A

5

28
Q

Which alpha 1 antagonists are selective?

Selective for which sub-types?

A

Tamsulosin
Silodosin

Alpha 1A and alpha 1D

29
Q

What converts serum testosterone to DHT in cells?

A

5alpha-reductase (I and II)

30
Q

Which PDE-5I has the longest efficacy and half life?

A

Tadalafil

31
Q

What are the direct effects of SARII inhibition?

Indirect?

A

Testosterone accumulation and DHT depletion

AR receptor less occupied

32
Q

Which SAR inhibitor is non-specific?

For what?

A

Dutasteride

SAR I and II

33
Q

What PDE5I is FDA approved for treatment of BPH?

A

Tadalafil

34
Q

Blood vessels alpha subtype receptor?

A

alpha 1B >/equal to alpha 1A

35
Q

Alfuzosin has what adverse effects?

A

QT prolongation

36
Q

How are SAR inhibitors metabolized?

Caution for use when?

A

CYP3A

Liver abnormality