Puthoff Lecture 2 Flashcards
What phase of ATI shows hypokalemia?
Recovery
Ischemic necrosis causes what kind of damage and where?
Patchy
PCT, PST, TAL
Defect of thin basement membrane disease due to a mutation in what?
Alpha3 or alpha4 type 4 collagen
What is being describe with these classic features?
Fever Microangiopathic hemolytic anemia Thrombocytopenia Neurologic symptoms Renal failure (50% of Pts)
TTP
How long does the initiation phase of ATI last?
What symptom?
36 hours
Oliguria
Papillary necrosis is caused by what?
DM
Analgesic nephropathy
Obstruction
Tubulointerstitial nephritis is characterized by what?
Azotemia
Inability to concentrate the urine
Polyuria
What is associated with non-epidemic, non-diarrheal, inherited mutations of proteins that regulate complement?
Atypical HUS
End stage diabetic nephrosclerosis can produce what?
Diffuse granular pitted surface
Marked thinning of renal cortex
Xanthogranulomatous pyelonephritis is often associated with what?
Proteus
What is the following morphology describing?
Diffuse capillary BM thickening
Diffuse Mesangial sclerosis
Nodular glomerulosclerosis
Diabetic glomerulosclerosis
What is associated with bloody diarrhea due to E. coli and is an epidemic snydrome?
Typical HUS
What injury causes PCT cells to swell and show vacuolization?
Ethylene glycol
Atypical HUS mostly seen in whom?
Pregnant
Immunosuppressed
Malignant HTN
Where are the most mitochondria (highest energy requirements) located in the tubules?
PCT
Papillary necrosis with pale gray necrosis limited to the papilla is caused by what?
DM
Most patients are ______ for the defective gene in thin basement membrane disease
Heterozygous
Autosomal inheritance
What anatomic defects predispose to pyelonephritis?
VUR
Intrarenal reflux
Diffuse proliferative lupus nephritis is characterized by what morphologically?
Increase in cellularity
Enlarged glomerulus
Decrease in urinary space
What is described by the following morphology?
Hyaline arteriosclerosis, cortical adherence, compressed lumen?
Benign nephrosclerosis
50% of children with UTI have what?
VUR
What disease shows “wire loops” on light microscopy and subendothelial dense deposits on EM?
Lupus nephritis