Urinary Embryology - Cole Flashcards
Pronephros
Cervical
Week 4
Nonfunctional, disappear day 24
Mesonephros
Week 4, second primitive kidney
Functional week 6 - 10, then degenerates
40 tubules that develop in craniocaudal succession
Metanephros 2 parts
Metanephric blastema - renogenic region
Ureteric bud - induced by blastema
What does the urinary system develop from?
Intermediate mesoderm
-lateral folding
What becomes the vas deferens in the male?
Mesonephric duct
In utero function of metanephros
Blood plasma filtered by 10th week
Supplement production of amniotic fluid
Where are kidneys formed?
In pelvis, ascend to lumbar region with progressive revasuclarization from common iliac and aorta
-accessory renal a common
Development of urinary bladder
Mesonephric duct (into urethra) and ureteric bud incorporated into the posterior wall of urinary bladder
Extrophy of the bladder
Failure of midline closure of inferior abdominal m, widely spaced pubic symphysis
Bifid clitoris and penis
4 possible urachus anomalies
- Patent urachus - open
- Urachus sinus - caudal open
- Bladder diverticulum - distal open
- Urachal cyst
Bifid ureter
Ureteric bud branches abnormally before it reaches the metanephric blastema
Duplicate or ectopic ureter
2 ureteric buds
Ectopic orifice can open anywhere
Bilateral renal agenesis
Incompatible with life
Oligohydramnios and associated hypo plastic lungs
Potter Facies - squished
Congenital polycystic kidney disease
Autosomal recessive
Multifocal lesions
Dilation and cyst formation and destruction of the surrounding tissues
Adult polycystic kidney
Autosomal dominant
Nephron développement is grossly disturbed
Renal failure by middle age
