Urinary antiseptics Flashcards
What are the urinary tract antiseptics?
Methenamine
Nitrofurantoin
How does Methenamine work?
Decomposes in water into formaldehyde and ammonia
True or False: Acidic urine is bad when using methenamine
False
acidification of the urine increases formation of the formaldehyde/ammonia
Methenamine is usually formulated with what? Why?
Formulated with mandelate or hippurate
These acidify the urine
When is methenamine contraindicated?
Contraindicated in hepatic disease because of ammonia
How is methenamine administered?
Orally
It’s given orally and concentrated in the urine
Besides UTI’s, what else is methenamine used for?
Chronic suppressive therapy against e coli
UTI prophylaxis?
How does Nitrofurantoin work?
It is reduced rapidly inside bacteria and its reduced for damages bacterial DNA
Is nitrofurantoin bacteriostatic or bacteriocidal?
Cidal
Counseling points on nitrofurantoin?
Colors urine orange-brown
What is nitrofurantoin active against?
E coli, enterococci
Toxicity with nitrofurantoin?
Nausea, vomiting, diarrhea, sensitivity reactions
Headache, vertigo, drowsiness, muscular aches, nystagmus
Pulmonary fibrosis on chronic therapy
Elderly are more susceptible
