Protein Synthesis Inhibitors (Overview) Flashcards
1
Q
Name the protein synthesis inhibitor classes
A
Aminoglycosides Tetracyclines Glycylcyclins Macrolides Lincosamides Chloramphenicol Streptogramins Oxazolidinones Mupirocin
2
Q
Name the aminoglycosides
A
Neomycin Gentamicin Amikacin Streptomycin Tobramycin Kanamycin
3
Q
Name the Tetracyclines
A
Tetracycline
Doxycycline
4
Q
Name the Glycylcyclins
A
Tigecyclin (also considered 2nd gen tetracycline)
5
Q
Name the Macrolides
A
Erythromycin
Clarithromycin
6
Q
Name the Lincosamides
A
Clindamycin
7
Q
Name the Streptogramins
A
Quinupristin
Dalfopristin
8
Q
Name the Oxazolidones
A
Linezolid
9
Q
Why don’t protein synthesis inhibitors kill us? They inhibit protein synthesis…
A
Bc they target bacterial cell 30s and 50s ribosomal subunits
We have 40s and 60s subunits
10
Q
Are protein synthesis inhibitors bacteriostatic or bacteriocidal?
A
Most bacteriostatic
except for Aminoglycosides and Mupirocin
