Urinary Flashcards
Breed, Sex, and Age Predispositions for… Urinary Calculi Struvite?
Miniature Schnauzers, Bichon Frises, Cocker Spaniels, Shih Tzus, Miniature Poodles, Lhasa Apsos
- Females more than males, middle-aged dogs
- Urinary tract infection with urease-producing bacteria (e.g., Proteus, Staphylococcus)
Calcium Oxalate?
- Miniature Schnauzers, Shih Tzus, Pomeranians, Yorkshire Terriers, Maltese, Lhasa Apsos, Bichon Frises, Cairn Terriers, Miniature Poodles
- Males, neutered males more than intact males, middle-aged to older dogs, obese dogs
Calcium Phosphate
Yorkshire terrier
Urate
• Dalmatians and English Bulldogs • Dogs with congenital portosystemic shunts (Yorkshire Terriers, Miniature Schnauzers, Pekingese)
Silicate?
• German Shepherds, Old English Sheepdogs • Males, middle-aged dogs
Cystine?
• Dachshunds, Basset Hounds, English Bulldogs, Newfoundlands, Chihuahuas, Miniature Pinschers, Welsh Corgis, Mastiffs, and Australian Cattle Dogs • Males, middle-aged dogs
Low; Evaluation of trends in urolith composition and characteristics of dogs with urolithiasis: 25,499 cases. JAVMA 2010 Over the past 20 years, a long-term increase in the proportion of canine urinary calculi that contain ______________ has been noted, along with a long-term decrease in the proportion of canine urinary calculi that contain ___________
calcium oxalate; struvite
Low; Evaluation of trends in urolith composition and characteristics of dogs with urolithiasis: 25,499 cases. JAVMA 2010; Male of female dogs have more struvite?
Female dogs tend to have more struvite-containing calculi than male dogs, most likely owing to the association with urinary tract infection
Pathophys of struvite calculi in dogs
Struvite (magnesium ammonium phosphate) caused by UTI with urease-producing bacteria, which split urea to ammonia and carbon dioxide. Hydrolysis of ammonia forms ammonium ions and hydroxyl ions, which alkalinize the urine and decrease struvite solubility.
Calcium oxalate calculi occur most commonly in dogs with what?
transient, postprandial hypercalcemia and hypercalciuria. Many affected dogs have low-to-normal serum parathormone concentrations.
Urate calculi usually are composed of _________________ derived from metabolic degradation of endogenous______ribonucleotides and dietary nucleic acids. Dalmatians have defective hepatic transport of____________, resulting in decreased production of ___________ and increased urinary excretion of__________. Dalmatians also have decreased ___________ resorption and _________ secretion of uric acid, making urate urolithiasis common in this breed.
Urate calculi usually are composed of ammonium acid urate derived from metabolic degradation of endogenous purine ribonucleotides and dietary nucleic acids. Dalmatians have defective hepatic transport of uric acid, resulting in decreased production of allantoin and increased urinary excretion of uric acid. Dalmatians also have decreased proximal tubular resorption and distal tubular secretion of uric acid, making urate urolithiasis common in this breed.
Treatment for Urate stones?
Urate
• Surgical removal; • Voiding hydropropulsion if stones are small enough; • Dissolve stones using alkalinization with sodium bicarbonate or potassium citrate; feed Hill’s u/d diet; administer allopurinol
Treatment for cystine stones?
Surgical removal; • Dissolve stones by feeding Hill’s u/d diet and administering D-penicillamine or N-(2-mercaptopropionyl)-glycine (MPG)
Silicate uroliths are often ____shaped and probably are related to increased dietary intake of silicates, silicic acid, or magnesium silicate (Fig. 26-31). Two breeds that are at increased risk for formation of silica-containing urinary calculi???
jack shaped; GSD and Old English Sheepdog
Cystine uroliths occur because of an inherited disorder of ____________ __________ __________. Cystine stones usually occur in _____ urine
Cystine uroliths occur because of an inherited disorder of renal tubular transport. Cystine stones usually occur in acidic urine.
Low Javma 2010 paper: Urate uroliths most commonly occur in Dalmatians and PSS dogs; however, a predisposition in what other breed has recently been recognized?
Not just Dalmations and shunt dogs…..English Bulldogs too!
Grant Holmium:YAG lithotripsy for urolithiasis in dogs. AJVR, 2008,
?
Lulich, JP, Osborne, CA, Albasan, H, et al.: Efficacy and safety of laser lithotripsy in fragmentation of urocystoliths and urethroliths for removal in dogs. J Am Vet Med Assoc. 234, 2009, 1279.
?
The most common complication following cystotomy is failure to remove all the stones, which is reported to be as high as __% (Grant et al, 2010).
20%
Grant; Frequency of incomplete urolith removal, complications, and diagnostic imaging following cystotomy for removal of uroliths from the lower urinary tract in dogs: 128 cases (1994-2006). J Am Vet Med Assoc. 2010
- 20% incomplete removal rate after cystotomy - in the very few (15%) that had “appropriate postop imaging”, 42% had incomplete removal - patients with both cysto- and urethra-liths had a higher likelihood of incomplete removal
Hypothesized that variation in bladder tumors in dogs vs cats d/t differences in the metabolism of ________ and its carcinogenic intermediary metabolites. Although dogs excrete aromatic amine metabolites of ________ in appreciable quantities into their urine, feline urine is almost devoid of them. Prolonged contact of the bladder mucosa with such carcinogenic substances may be important in the development of tumor.
tryptophan; tryptophan
What drug may cause bladder neoplasia in dogs?
Cyclophosphamide may also cause bladder neoplasia in dogs
Besides TCC; other malignant bladder tumors? (name at least 5). Dont forget this one: A rare bladder tumor that may occur in young large-breed dogs and young cats.
TCCs are the most common tumors in canine and feline bladders; other malignant bladder tumors include squamous cell carcinoma, adenocarcinoma, fibrosarcoma, leiomyosarcoma, neurofibrosarcoma, rhabdomyosarcoma, and hemangiosarcoma. The rare tumor is Botryoid Rhabdomyosarcoma
Benign bladder tumors?
Fibroma, leiomyoma, hemangioma, rhabdomyoma, myxoma, and neurofibroma are benign bladder tumors.