Urinary Flashcards
What leads to Albuminuria
Damage to glomerular capillaries
Lowered albumin in blood has what effect
Makes it hypotonic
Fluid moves via osmosis from blood into tissues
Blood volume DECREASES & interstitial fluid volume increases causing oedema
How is oedema caused
Glomerular capillaries damaged, become leaky
Leads to plasma protein loss -Albuminuria
Blood then becomes hypotonic, fluid leaks into tissues
Blood volume decreased interstitial fluid volume increases causing oedema
What is RENIN
An enzyme secreted by kidneys if BP too low
What does Renin do
Converts angiotensinogen from liver into angiotensin 1
What is ACE and what secretes it
Angiotensin converting enzyme
Secreted by lungs & kidneys
What does angiotensin converting enzyme do
Converts angiotensin 1 into angiotensin 2 it’s active form
Why do kidneys secrete renin if BP too low
Because require adequate pressure to filter blood
3 actions of angiotensin 2
Triggers vasoconstriction
Triggers pituitary gland to release ADH
stimulates adrenal cortex to produce aldosterone
2 actions of aldosterone
Causes kidneys to retain Na
And extrete K
Effect of retaining Na and excreting K in blood
Causes water retention
Increases blood volume & pressure
When is ADH secreted
Reduced water concentration in blood & lowered blood volume (sweating/haemorrhage)
Effect of ADH
Increases permeability of distal convoluted tubules, increasing water re absorption, rebalancing osmotic pressure
What is ANP
Atrial natriuretic peptide
Released from heart
When does heat release atrial natriuretic peptide
Large increase in blood volume/pressure
Atrial natriuretic peptide is the opposite to
Angiotensin 2
Effect of calcitriol
Increases calcium & phosphorous absorption/retention
Increases bone calcification
Plasma protein loss
Albuminuria
definition glomerular sclerosis
scarring/fibrosis of glomerular capillaries
scarring/fibrosis glomerular capillaries
glomerular sclerosis
definition nephrotic syndrome
leaky glomeruli
leaky glomeruli
nephrotic syndrome
2 causes glomerular sclerosis
diabetes (end stage)
glomerulonephritis
5 causes nephrotic syndrome
glomerulonephritis diabetic glomerulsclerosis systemic lupus erythmatosus infections (malaria. hepatitis) drug treatments
glomerulonephritis diabetic glomerulosclerosis systemic lupus erythmatosus infections drug treatments cause
nephrotic sydrome
s/sx glomerular sclerosis
congestion of glomerular capillaries inhibits blood flow
leads to high BP as kidneys produce more renin to increase blood flow & restore GFR
congestion of glomerular capillaries inhibits blood flow
leads to high BP as kidneys produce more renin to
increase blood flow & restore GFR
glomerular sclerosis
s/sx nephrotic syndrome
albumiuria - low plasma osmotic pressure & hypotonic capillaries so fluid moves into tissues throughout body - oedema
weight gain, pallor
nephrotic syndrome BP?
Normal