Urinary

Question 1

Oxybutynin:
- mech
- indication
- se

Answer 1

Oxybutynin:
- mech: m3 antagonist causes relaxation detrusor muscle
- indic: urge
- se: diarrhea, dry eye, postural hypotension
- antimusc: constip, dizzy, dry mouth, headache, tachyc

Question 2

Solifenacin
- mech
- indic
- se

Answer 2

• mech: antimusc causing relaxation detrusor
• indic: urge
• se: gi discomfort
• interactions: cyp3a4 inhib

Question 3

Mirabegron
- mech
- use
- se

Answer 3

• mech: b3 agonist in sns relaxes detrusor
• use: urge
• se: arrythmia, constip, dizzy, diarr, inc risk infection
• contraind: uncontrolled htn, qt prolongation

Question 4

Duloxetine
- mech
- use
- se

Answer 4

• mech: snri inhibits reuptake na therefore inc sphincter contraction, reduce gradually over 2 weeks
• use: sui, depression, GAD
• se: anxiety, appetite dec, constip, diarr, dizzy, gi discomfort

Question 5

Finasteride (sildenafil):
- mech
- uses
- se

Answer 5

• mech: 5 alpha reductase inhib stops test -> dihydrotest reducing prostate vol but takes 6 months to work
• uses: bph
• se: ED, reduced libido, gynaecomastia, arrythmia, chest pain, cough, dizzy, dry mouth, psych se

Question 6

Tamsulosin:
- mech
- uses
- se

Answer 6

• mech: alpha blocker which relaxes sm of prostate
• uses: bph
• SE: postural hypotension, dizzy, ED, dry mouth, depression