Pain

Question 1

NSAIDs:
- mech action
- contraind

Answer 1

NSAIDs:
- mech action: analgesic + antiinflammatory actions - cox inhibitor causing decreased prostaglandin inhibition
- contraind: hx PUD, GI bleeding, asthma, renal impairment, dehydrated, hypersens to nsaids/aspirin

Question 2

Paracetamol:
- mech action
- se

Answer 2

Paracetamol:
- mech action: inhibits prostaglandin synthesis, analgesic + antipyretic effect
- se: hepatotoxicity in overdosage

Question 3

Opioids:
- types
- se

Answer 3

Opioids:
- types: morphine, pethidine (10% potency of morphine, has toxic metabolite so not good in renal failure), codeine
- se: n+v, constipation, resp depression
- caution: liver disease, elderly