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Question 1

Inducers of p450 enzyme (inc breakdown of other drugs)

Answer 1

antiepileptics (phenytoin, carbamezapine)
barbiturates (phenobarbitone)
rifampicin
st johns wort
chronic alcohol intake
griseofulvin
smoking

Question 2

Inhibitors of p450 enzyme (inc product)

Answer 2

abx (ciprofloxacin, erythromycin)
isoniazid
omeprazole, cimetidine
allopurinol
amiodarone
imidazoles (ketoconazole, fluconazole)
ssris (fluoxetine, sertralin)
ritonavir
sodium valp
acute alc intake
quinupristin

Question 3

Carbon monoxide poisoning
- pathophy
- symp
- ix
- mx

Answer 3

Carbon monoxide poisoning
- pathophy: CO binds to hb as higher affinity means less oxy carrying capacity (R->L shift) dec oxygen sats
- symp: headache, n+v, vertigo, confusion, weak, if sev pink skin/mucosa/hyperpyrexia/arrythmia
- ix : (pulse oximetry may be falsely high), vbg/abg
- mx: 100% high flow oxy, hyperbaric oxy