Respiratory drugs Flashcards
1
Q
salbutamol
- mech action
- indication
- se
A
- mech action: saba agonist, acts on b2 rec to dec camp hence cause bronchial sm relaxation (however receptors can downgrade causing tolerance
- indic: reliever and preventer prior to exercise
- se: hypokalamia, fine tremor, myalgia, cough, headache, palpits/tachyc
2
Q
salmeterol:
- mech action
- indication
- se
- contraind
A
- mech action: laba
- indication: use if salbut gives cough, don’t use alone as can mask airway inflammation
- se: muscle cramps, palpits, hyperglyc, headaches, svt/angina due to tachycardia
- containd: b blockers, hypokal
3
Q
beclometasone:
- mech action
- se
A
- mech action: ics, binds glucocort rec inc b2 rec and dec inflammatory mediator production
- se: candidiasis, pneumonia, hoarse voice, stunts growth
4
Q
tiotropium
- mech action
- se
A
- mech action: lama antag, blocks ach rec at m3 stopping vagally mediated bronchoconst
- se: antichol se (dry mouth, urin retention, dry eyes)
5
Q
montelukast:
- mech action
- indication
- se
A
- mech action: ltra antag, stops leukotriene released by mast cells causing bronchoconst + mucus secretion
- se: headaches, gi upset, dry mouth
6
Q
theophylline:
- mech action
- indication
- se
A
- mech action: adenosine rec antag reduces bronchoconstiction
- indication
- se: arrythmias, headache, gi upset, reflux, dizzy - monitor bp/hr when iv infusion bc narrow therapeutic index
